PMID- 14506092
OWN - NLM
STAT- MEDLINE
DCOM- 20040914
LR  - 20131121
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 96
IP  - 2
DP  - 2004 Feb
TI  - Interferon-gamma increases monocyte HLA-DR expression without effects on glucose 
      and fat metabolism in postoperative patients.
PG  - 597-603
AB  - Tissue injury is associated with decreased cellular immunity and enhanced 
      metabolism. Immunodepression is thought to be counteracted by interferon 
      (IFN)-gamma, which increases human leukocyte antigen (HLA)-DR expression. 
      Hypermetabolism could be enhanced by IFN-gamma because cytokines induce a 
      hypermetabolic response to stress. In healthy humans, IFN-gamma enhanced HLA-DR 
      expression without effects on glucose and fat metabolism. In the present study, 
      we evaluated whether IFN-gamma lacks potential harmful side effects on metabolic 
      and endocrine pathways while maintaining its beneficial effects on the immune 
      system under conditions in which the inflammatory response system is activated. 
      In 13 patients scheduled for major surgery, we studied HLA-DR expression on 
      peripheral blood monocytes before surgery and postoperatively randomized the 
      patients into an intervention and a placebo group. Subsequently, we evaluated the 
      effects of a single dose of IFN-gamma vs. saline on short-term monocyte 
      activation, glucose and lipid metabolism, and glucose and lipid regulatory 
      hormones. HLA-DR expression on monocytes was restored from postoperative levels 
      of 54% (42-60%; median and interquartiles) to 92% (91-96%) 24 h after IFN-gamma 
      administration but stayed low in the placebo-treated patients. IFN-gamma did not 
      affect glucose metabolism (plasma glucose, rate of appearance and disappearance 
      of glucose) and lipid metabolism (plasma glycerol, plasma free fatty acids, and 
      rates of appearance and disappearance of glycerol). IFN-gamma had no effect on 
      plasma cortisol, adrenocorticotropic hormone, growth hormone, insulin, C-peptide, 
      glucagon, epinephrine, and norepinephrine concentrations. We conclude that 
      IFN-gamma exerts a favorable effect on cell-mediated immunity in patients after 
      major surgery without effects on glucose and lipid metabolism.
FAU - de Metz, Jesse
AU  - de Metz J
AD  - Department of Endocrinology and Metabolism, Academic Medical Center, 1100 DD 
      Amsterdam, The Netherlands.
FAU - Romijn, Johannes A
AU  - Romijn JA
FAU - Endert, Erik
AU  - Endert E
FAU - Ackermans, Mariette T
AU  - Ackermans MT
FAU - Weverling, Gerrit Jan
AU  - Weverling GJ
FAU - Busch, Olivier R
AU  - Busch OR
FAU - de Wit, Laurence Th
AU  - de Wit LT
FAU - Gouma, Dirk J
AU  - Gouma DJ
FAU - ten Berge, Ineke J M
AU  - ten Berge IJ
FAU - Sauerwein, Hans P
AU  - Sauerwein HP
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20030923
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Hormones)
RN  - 82115-62-6 (Interferon-gamma)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Aged
MH  - Antineoplastic Agents/*administration & dosage
MH  - Blood Glucose/drug effects/*metabolism
MH  - Energy Metabolism/drug effects
MH  - Female
MH  - Glycerol/metabolism
MH  - HLA-DR Antigens/*metabolism
MH  - Hormones/blood
MH  - Humans
MH  - Interferon-gamma/*administration & dosage
MH  - *Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*drug effects/metabolism
MH  - Postoperative Period
EDAT- 2003/09/25 05:00
MHDA- 2004/09/15 05:00
CRDT- 2003/09/25 05:00
PHST- 2003/09/25 05:00 [pubmed]
PHST- 2004/09/15 05:00 [medline]
PHST- 2003/09/25 05:00 [entrez]
AID - 00090.2002 [pii]
AID - 10.1152/japplphysiol.00090.2002 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2004 Feb;96(2):597-603. doi: 
      10.1152/japplphysiol.00090.2002. Epub 2003 Sep 23.