PMID- 1450621
OWN - NLM
STAT- MEDLINE
DCOM- 19930107
LR  - 20221207
IS  - 0941-0198 (Print)
IS  - 0941-0198 (Linking)
VI  - 70
IP  - 10
DP  - 1992 Oct
TI  - HLA-DRB3 gene alleles in Caucasian patients with Graves' disease.
PG  - 956-60
AB  - Graves' disease (GD) is a human leukocyte antigen (HLA) linked organ-specific 
      autoimmune disease. In German GD patients the disease is associated with HLA 
      specificities of the HLA-DRw52 family (HLA-DR3, -DR5, and DR6; HLA-DRB3 positive 
      HLA haplotypes). Recently, a strong association with a HLA-DRB3 restriction 
      fragment length polymorphism gene has been described. To study HLA-DRB3 alleles 
      and their association with the disease, a large cohort of controls (n = 3724) and 
      GD patients (n = 304) was analyzed. HLA-DR allelic combinations revealed an 
      increase in HLA-DR3/DR5 heterozygous patients (relative risk 2.9; P < 0.001). 
      HLA-DRB3 alleles, as defined by DNA typing in HLA-DR matched groups revealed a 
      significant increase in DRB3*0101 homozygosity (relative risk 17.5; P < 0.001) in 
      HLA-DR3 homozygous patients. In GD patients with ophthalmopathy (grade II or 
      higher, according to Werner) DRB3*0101/*0202 heterozygosity revealed an increased 
      relative risk of 5.5 (P < 0.001). Non-HLA-DR3 homozygous, DRB3*0101/*0202 
      heterozygous patients were at the highest risk for endocrine ophthalmopathy 
      (relative risk 10; P < 0.001). Our data, based on DNA typing methods of HLA-D 
      genes, provide evidence that the susceptibility is strongly associated with 
      HLA-DRB3 genes.
FAU - Boehm, B O
AU  - Boehm BO
AD  - Klinikum der Johann Wolfgang Goethe-Universitat, Zentrum der Inneren Medizin, 
      Frankfurt, Main.
FAU - Kuhnl, P
AU  - Kuhnl P
FAU - Manfras, B J
AU  - Manfras BJ
FAU - Chen, M
AU  - Chen M
FAU - Lee, J C
AU  - Lee JC
FAU - Holzberger, G
AU  - Holzberger G
FAU - Seidl, S
AU  - Seidl S
FAU - Schifferdecker, E
AU  - Schifferdecker E
FAU - Schumm-Draeger, P M
AU  - Schumm-Draeger PM
FAU - Usadel, K H
AU  - Usadel KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Investig
JT  - The Clinical investigator
JID - 9207154
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB3 Chains)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Base Sequence
MH  - Biomarkers/blood
MH  - DNA/analysis
MH  - Graves Disease/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB3 Chains
MH  - Heterozygote
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serologic Tests
MH  - White People/*genetics
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 10.1007/BF00180447 [doi]
PST - ppublish
SO  - Clin Investig. 1992 Oct;70(10):956-60. doi: 10.1007/BF00180447.