PMID- 14506926
OWN - NLM
STAT- MEDLINE
DCOM- 20040309
LR  - 20190922
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 50
IP  - 1
DP  - 2003 Jul
TI  - Deficient expression of tumor necrosis factor receptor type 2 in the endometrium 
      of women with endometriosis.
PG  - 33-40
AB  - PROBLEM: Tumor necrosis factor-alpha (TNF-alpha) is secreted mainly during the 
      menstrual phase and has been suggested to play a role in induction of apoptosis 
      in endometrial cells and menstrual shedding. TNF-alpha receptor type 2 (TNF-RII) 
      is believed to play a central role in TNFalpha-mediated cytotoxic, mitogenic, 
      anti-proliferative and apoptotic effects. The aim of this study was to assess 
      whether TNF-RII maybe expressed differentially in the endometrium of women with 
      different degrees of endometriosis. METHOD OF STUDY: TNF-RII expression in the 
      endometrial tissue of women with and without endometriosis was investigated by 
      immunohistochemical techniques and in situ hybridization. RESULTS: In 
      histological sections, we observed TNF-RII mRNA and the corresponding protein 
      localized mainly in endometrial glandular cells, with only very faint 
      immunostaining in the surrounding stromal cells. Statistical analysis of our data 
      showed a significant decrease in protein and mRNA expression of TNF-RII in 
      endometrial glandular cells of patients with stages I and II endometriosis 
      compared to normal subjects. TNF-RII expression was also found to decrease 
      significantly in the secretory phase of the menstrual cycle in women with early 
      endometriosis stages (I and II). CONCLUSIONS: In view of the relevant role of 
      TNF-RII in the modulation of the inflammatory and the proapoptotic effects of 
      TNFalpha, deficient expression of TNF-RII mRNA in the endometrium of women at the 
      earliest stages of endometriosis may play a significant role in the 
      pathophysiology of this disease.
FAU - Kharfi, Abdelaziz
AU  - Kharfi A
AD  - Centre de Recherche, Hopital Saint-Francois d'Assise, Centre Hospitalier 
      Universitaire de Quebec, Faculte de Medecine, Universite Laval, Quebec, Canada.
FAU - Labelle, Yves
AU  - Labelle Y
FAU - Mailloux, Jacques
AU  - Mailloux J
FAU - Akoum, Ali
AU  - Akoum A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Antigens, CD)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
SB  - IM
MH  - Adult
MH  - Antigens, CD/genetics/*metabolism
MH  - Endometriosis/*metabolism/pathology
MH  - Endometrium/chemistry/*metabolism/pathology
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - In Situ Hybridization, Fluorescence/methods
MH  - RNA, Messenger/metabolism
MH  - Receptors, Tumor Necrosis Factor/genetics/*metabolism
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - U937 Cells
EDAT- 2003/09/26 05:00
MHDA- 2004/03/10 05:00
CRDT- 2003/09/26 05:00
PHST- 2003/09/26 05:00 [pubmed]
PHST- 2004/03/10 05:00 [medline]
PHST- 2003/09/26 05:00 [entrez]
AID - 10.1034/j.1600-0897.2003.00058.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2003 Jul;50(1):33-40. doi: 10.1034/j.1600-0897.2003.00058.x.