PMID- 14506987
OWN - NLM
STAT- MEDLINE
DCOM- 20031212
LR  - 20191108
IS  - 0179-051X (Print)
IS  - 0179-051X (Linking)
VI  - 18
IP  - 3
DP  - 2003 Summer
TI  - Are manometric parameters of the upper esophageal sphincter and pharynx affected 
      by age and gender?
PG  - 211-7
AB  - The effects of age and gender on the upper esophageal sphincter's (UES) and 
      pharyngeal manometric parameters were investigated in 84 healthy subjects (45 
      men, 39 women, mean age = 44 years, range = 18-91). Manometric recordings were 
      performed with solid-state circumferential transducers. Subjects older than 60 
      years (n = 23) showed a significant lower UES resting pressure. In addition, 
      during water swallows they had a higher UES residual pressure, shorter UES 
      relaxation interval and UES relaxation duration, and a decreased UES relaxation 
      rate. Furthermore, pharyngeal contraction had significant higher amplitude and 
      longer duration in subjects older than 60 years during water swallows. Some of 
      these findings were also observed during cookie and pudding swallows. Women had a 
      higher UES resting pressure and a longer UES relaxation interval than men. The 
      observed changes with increasing age indicate loss of basal tone and decreased 
      compliance of the UES. Increased pharyngeal contraction amplitude and its 
      prolonged duration in the elderly might be compensatory to this. These 
      physiologic effects of age and gender on UES and pharyngeal parameters should be 
      taken into account during analysis of manometric studies.
FAU - van Herwaarden, Margot A
AU  - van Herwaarden MA
AD  - Gastrointestinal Research Unit, Departments of Gastroenterology and Surgery, 
      University Medical Center Utrecht, The Netherlands. M.vanherwaarden@zonnet.nl
FAU - Katz, Phil O
AU  - Katz PO
FAU - Gideon, R Matthew
AU  - Gideon RM
FAU - Barrett, Jeff
AU  - Barrett J
FAU - Castell, June A
AU  - Castell JA
FAU - Achem, S
AU  - Achem S
FAU - Castell, Donald O
AU  - Castell DO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dysphagia
JT  - Dysphagia
JID - 8610856
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Deglutition/*physiology
MH  - Esophagogastric Junction/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Manometry
MH  - Middle Aged
MH  - Pharynx/*physiology
MH  - Reference Values
MH  - Sex Factors
EDAT- 2003/09/26 05:00
MHDA- 2003/12/13 05:00
CRDT- 2003/09/26 05:00
PHST- 2003/09/26 05:00 [pubmed]
PHST- 2003/12/13 05:00 [medline]
PHST- 2003/09/26 05:00 [entrez]
AID - 10.1007/s00455-002-0099-7 [doi]
PST - ppublish
SO  - Dysphagia. 2003 Summer;18(3):211-7. doi: 10.1007/s00455-002-0099-7.