PMID- 14507468
OWN - NLM
STAT- MEDLINE
DCOM- 20031126
LR  - 20190910
IS  - 0162-0134 (Print)
IS  - 0162-0134 (Linking)
VI  - 97
IP  - 1
DP  - 2003 Sep 15
TI  - Brain-derived neurotrophic factor protects cultured rat hippocampal neurons from 
      aluminum maltolate neurotoxicity.
PG  - 124-31
AB  - Aluminum is environmentally abundant but not an essential trace element. Although 
      there is increasing evidence suggesting the implication of aluminum in the 
      pathogenesis of Alzheimer's disease, it is still controversial. We found and 
      report here that aluminum maltolate, a stable and hydrophilic aluminum complex, 
      causes death of primary cultured rat hippocampal neurons in a time- and 
      dose-dependent manner. Degenerated neurons were TUNEL-positive. 
      Immunohistochemical detection of synapsin I and microtubule associated protein 2 
      revealed the synapse loss between neurons intoxicated by aluminum maltolate. To 
      explore the mechanism underlying its neurotoxicity, we administered various 
      pharmacological compounds prior to the application of aluminum maltolate, and 
      found that brain-derived neurotrophic factor (BDNF) markedly attenuated the 
      neurotoxicity. Furthermore, aluminum maltolate inhibited the elevation of 
      intracellular calcium levels caused by BDNF. Our results suggest the involvement 
      of BDNF in the molecular mechanism underlying neurotoxicity induced by aluminum 
      maltolate.
FAU - Kawahara, Masahiro
AU  - Kawahara M
AD  - Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute 
      for Neuroscience, Tokyo, Japan. kawamasa@phoenix.ac.jp
FAU - Kato-Negishi, Midori
AU  - Kato-Negishi M
FAU - Hosoda, Ritsuko
AU  - Hosoda R
FAU - Imamura, Lisa
AU  - Imamura L
FAU - Tsuda, Masaaki
AU  - Tsuda M
FAU - Kuroda, Yoichiro
AU  - Kuroda Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Pyrones)
RN  - 0 (Synapsins)
RN  - 23058-19-7 (aluminum maltolate)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Calcium/analysis/chemistry
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Drug
MH  - Hippocampus/cytology/*drug effects/metabolism
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Microtubule-Associated Proteins/ultrastructure
MH  - Neurons/cytology/*drug effects/metabolism
MH  - Neuroprotective Agents/pharmacology
MH  - Organometallic Compounds/*antagonists & inhibitors/pharmacology/*toxicity
MH  - Pyrones/*antagonists & inhibitors/pharmacology/*toxicity
MH  - Rats
MH  - Synapsins/ultrastructure
MH  - Time Factors
EDAT- 2003/09/26 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/09/26 05:00
PHST- 2003/09/26 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/09/26 05:00 [entrez]
AID - S0162013403002551 [pii]
AID - 10.1016/s0162-0134(03)00255-1 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2003 Sep 15;97(1):124-31. doi: 10.1016/s0162-0134(03)00255-1.