PMID- 14510284
OWN - NLM
STAT- MEDLINE
DCOM- 20031016
LR  - 20191108
IS  - 1050-6934 (Print)
IS  - 1050-6934 (Linking)
VI  - 13
IP  - 2
DP  - 2003
TI  - Recommendations for postexposure prophylaxis of operating room personnel and 
      patients exposed to bloodborne diseases.
PG  - 103-16
AB  - The purpose of this collective review is to discuss management of operating room 
      personnel who have had occupational exposure to blood and other body fluids that 
      might contain hepatitis B virus (HBV), hepatitis C virus (HCV), human 
      immunodeficiency virus (HIV), and human T-cell lymphotropic virus type I 
      (HTLV-I). HBV postexposure prophylaxis includes starting hepatitis B vaccine 
      series in any susceptible unvaccinated operating room personnel who sustain an 
      exposure to blood or body fluid during surgery. Postexposure prophylaxis with 
      hepatitis B immune globulin (HBIG) is an important consideration after 
      determining the hepatitis B antigen status of the patient. Ideally, all operating 
      room personnel should be vaccinated with hepatitis B vaccine before they pursue 
      their career in surgery. Immune globulin and antiviral agents (e.g., interferon 
      with or without ribavirin) should not be used for postexposure prophylaxis of 
      operating room personnel exposed to patients with HCV; rather, follow-up HCV 
      testing should be initiated to determine if infection develops. Postexposure 
      prophylaxis for HIV involves a basic four-week regimen of two drugs (zidovudine 
      and lamivudine; lamivudine and stavudine; or didanosine and stavudine) for most 
      exposures. An expanded regimen that includes a third drug must be considered for 
      HIV exposures that pose an increased risk for transmission. When developing a 
      postexposure prophylaxis regimen, it is helpful to contact the National 
      Clinicians' Postexposure Prophylaxis Hotline (1-888-448-4911).
FAU - Edlich, Richard F
AU  - Edlich RF
AD  - Plastic Surgery Research Program, University of Virginia Health System, 
      Charlottesville, Virginia, USA. redlich9@attbi.com
FAU - Wind, Tyler C
AU  - Wind TC
FAU - Heather, Cynthia L
AU  - Heather CL
FAU - Degnan, Gregory G
AU  - Degnan GG
FAU - Drake, David B
AU  - Drake DB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Long Term Eff Med Implants
JT  - Journal of long-term effects of medical implants
JID - 9110830
RN  - 0 (Viral Hepatitis Vaccines)
MH  - Blood-Borne Pathogens
MH  - Equipment Failure
MH  - *Gloves, Surgical
MH  - HIV Infections/prevention & control/*transmission
MH  - Hepatitis/*prevention & control
MH  - Humans
MH  - Infectious Disease Transmission, Professional-to-Patient/*prevention & control
MH  - Occupational Exposure
MH  - *Operating Room Technicians
MH  - Viral Hepatitis Vaccines/*therapeutic use
RF  - 63
EDAT- 2003/09/27 05:00
MHDA- 2003/10/17 05:00
CRDT- 2003/09/27 05:00
PHST- 2003/09/27 05:00 [pubmed]
PHST- 2003/10/17 05:00 [medline]
PHST- 2003/09/27 05:00 [entrez]
AID - 10.1615/jlongtermeffmedimplants.v13.i2.50 [doi]
PST - ppublish
SO  - J Long Term Eff Med Implants. 2003;13(2):103-16. doi: 
      10.1615/jlongtermeffmedimplants.v13.i2.50.