PMID- 14510425
OWN - NLM
STAT- MEDLINE
DCOM- 20031031
LR  - 20191108
IP  - 3
DP  - 2003
TI  - Fluoreometric behavior of a novel bis-acridine orange bound to double stranded 
      DNA.
PG  - 151-2
AB  - Novel bis-acridine orange (1) was synthesized from Fmoc-Lys(Boc)-OH and 
      Fmoc-Lys(AO)-OH (AO: acridine orange), with the 9-position of acridine orange 
      (AO) linked to the epsilon-amino moiety of lysine, on the peptide synthesizer. 
      Bis-acridine orange (1) yielded a very weak fluorescence in an aqueous media due 
      to the intramolecular stacking, but its fluorescence was enhanced over 200-times 
      upon binding to double-stranded DNA, irrespective of the DNA sequences. Circular 
      dichroism (CD) spectra showed that 1 binds to double stranded DNA in its stacked 
      conformation, concomitant with fluorescence enhancement.
FAU - Takenaka, Shigeori
AU  - Takenaka S
AD  - Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 
      Fukuoka 812-8581, Japan.
FAU - Sakakibara, Yutaka
AU  - Sakakibara Y
FAU - Ueyama, Hiroyuki
AU  - Ueyama H
FAU - Nojima, Takahiko
AU  - Nojima T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucleic Acids Res Suppl
JT  - Nucleic acids research. Supplement (2001)
JID - 101169367
RN  - 9007-49-2 (DNA)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*chemistry
MH  - Circular Dichroism
MH  - DNA/*chemistry
MH  - Spectrometry, Fluorescence
EDAT- 2003/09/27 05:00
MHDA- 2003/11/01 05:00
CRDT- 2003/09/27 05:00
PHST- 2003/09/27 05:00 [pubmed]
PHST- 2003/11/01 05:00 [medline]
PHST- 2003/09/27 05:00 [entrez]
AID - 10.1093/nass/3.1.151 [doi]
PST - ppublish
SO  - Nucleic Acids Res Suppl. 2003;(3):151-2. doi: 10.1093/nass/3.1.151.