PMID- 14510953
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 123
IP  - 1
DP  - 2003 Oct
TI  - Phenotype, function and chimaerism of monocyte-derived blood dendritic cells 
      after allogeneic haematopoietic stem cell transplantation.
PG  - 119-26
AB  - Dendritic cells (DCs) are essential for initiating T-cell responses against 
      either host- or leukaemia-specific antigens. We analysed phenotype, 
      allostimulatory capacity and chimaerism of monocyte-derived DCs (moDCs) serially 
      in 28 patients receiving allogeneic stem cell grafts after conventional 
      myeloablative (n = 14) or reduced-intensity conditioning (RIC, n = 14). Although 
      the recovery of phenotype and function of moDCs after myeloablative stem cell 
      transplantation (SCT) was prompt, there was a trend to a lower expression of 
      co-stimulatory molecules and major histocompatibility antigen class II antigens 
      on mature moDCs in patients who had received RIC transplants. Similarly, the 
      allostimulatory capacity of mature moDCs after RIC transplants was reduced for up 
      to 6 months. Six out of 14 (43%) RIC transplant patients showed a pattern of 
      mixed chimaerism within the first 3 months after transplant. RIC transplant 
      patients with a mixed donor DC chimaerism had a significantly higher risk of 
      relapse (75% versus 35% for patients with full donor DC chimaerism, P = 0.03) but 
      a lower incidence of acute graft-versus-host disease (25% versus 56% for patients 
      with full donor DC chimaerism, P = 0.157). These data, although preliminary, 
      provide evidence that DC function is impaired after RIC transplants and that DC 
      chimaerism may have an impact on graft-versus-host and graft-versus-leukaemia 
      reactions.
FAU - Nachbaur, David
AU  - Nachbaur D
AD  - BMT Unit and Tumour- and Immunobiology Laboratory, Division of Haematology and 
      Oncology, Innsbruck University Hospital, Innsbruck, Austria. 
      david.nachbaur@uibk.ac.at
FAU - Kircher, Brigitte
AU  - Kircher B
FAU - Eisendle, Klaus
AU  - Eisendle K
FAU - Latzer, Karla
AU  - Latzer K
FAU - Haun, Margot
AU  - Haun M
FAU - Gastl, Gunther
AU  - Gastl G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chimera
MH  - Dendritic Cells/*immunology
MH  - Flow Cytometry
MH  - Graft vs Host Disease/immunology
MH  - Graft vs Leukemia Effect
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunophenotyping
MH  - Lymphocyte Culture Test, Mixed
MH  - Middle Aged
MH  - Minisatellite Repeats
MH  - Transplantation, Homologous
EDAT- 2003/09/27 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/09/27 05:00
PHST- 2003/09/27 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/09/27 05:00 [entrez]
AID - 4588 [pii]
AID - 10.1046/j.1365-2141.2003.04588.x [doi]
PST - ppublish
SO  - Br J Haematol. 2003 Oct;123(1):119-26. doi: 10.1046/j.1365-2141.2003.04588.x.