PMID- 14512160
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20190827
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 142
IP  - 1-2
DP  - 2003 Sep
TI  - Features of skin-coincubated macrophages that promote recovery from spinal cord 
      injury.
PG  - 10-6
AB  - Uncontrolled inflammation is considered to exacerbate the neuronal loss that 
      follows spinal cord trauma. However, controlled inflammation response appears to 
      be beneficial. Skin-coincubated macrophages injected into contused spinal cord of 
      rats resulted in improved motor recovery and reduced spinal cyst formation. The 
      macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 
      and MHC-II, markers characteristic of antigen presenting cells (APCs). 
      Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 
      beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of 
      tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by 
      skin-coincubation bolster neuroprotective immune activity in the spinal cord, 
      making the environment less cytotoxic and less hostile to axonal regeneration.
FAU - Bomstein, Yonit
AU  - Bomstein Y
AD  - Proneuron Biotechnologies, P.O. Box 277, Ness Ziona 74101, Israel.
FAU - Marder, Jonathan B
AU  - Marder JB
FAU - Vitner, Karen
AU  - Vitner K
FAU - Smirnov, Igor
AU  - Smirnov I
FAU - Lisaey, Galit
AU  - Lisaey G
FAU - Butovsky, Oleg
AU  - Butovsky O
FAU - Fulga, Valentin
AU  - Fulga V
FAU - Yoles, Eti
AU  - Yoles E
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/immunology/metabolism/transplantation
MH  - Behavior, Animal
MH  - Cytokines/metabolism
MH  - Injections, Intralesional
MH  - Macrophage Activation/immunology
MH  - Macrophages/*immunology/metabolism/transplantation
MH  - Male
MH  - Motor Activity/immunology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/*immunology
MH  - Spinal Cord Injuries/*immunology/pathology/physiopathology/*therapy
EDAT- 2003/09/27 05:00
MHDA- 2004/01/06 05:00
CRDT- 2003/09/27 05:00
PHST- 2003/09/27 05:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/09/27 05:00 [entrez]
AID - S0165572803002601 [pii]
AID - 10.1016/s0165-5728(03)00260-1 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 Sep;142(1-2):10-6. doi: 10.1016/s0165-5728(03)00260-1.