PMID- 14512170
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20190827
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 142
IP  - 1-2
DP  - 2003 Sep
TI  - Peripheral nerve induces macrophage neurotrophic activities: regulation of 
      neuronal process outgrowth, intracellular signaling and synaptic function.
PG  - 112-29
AB  - Rat cortical neurons cultured in conditioned media from human monocyte-derived 
      macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, 
      mitogen-activating protein kinase activity, and synaptic function. Neurotrophic 
      properties of human MDM-conditioned media are significantly enhanced by human 
      peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. 
      Such positive effects of MDM secretions on neuronal function parallel the 
      secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may 
      serve to balance toxic activities produced during neurodegenerative diseases and 
      thus, under certain circumstances, mitigate neuronal degeneration.
FAU - Shibata, Annemarie
AU  - Shibata A
AD  - Center for Neurovirology and Neurodegenerative Disorders and the Department of 
      Pathology and Microbiology, University of Nebraska Medical Center, 985215 
      Nebraska Medical Center, Omaha, NE 68198-5215, USA.
FAU - Zelivyanskaya, Marina
AU  - Zelivyanskaya M
FAU - Limoges, Jenae
AU  - Limoges J
FAU - Carlson, Kimberly A
AU  - Carlson KA
FAU - Gorantla, Santhi
AU  - Gorantla S
FAU - Branecki, Chad
AU  - Branecki C
FAU - Bishu, Shrinivas
AU  - Bishu S
FAU - Xiong, Huangui
AU  - Xiong H
FAU - Gendelman, Howard E
AU  - Gendelman HE
LA  - eng
GR  - 2R01 NS3423/NS/NINDS NIH HHS/United States
GR  - 2R37 NS 3613/NS/NINDS NIH HHS/United States
GR  - P01 MH050244/MH/NIMH NIH HHS/United States
GR  - P01 NS 31492/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Nerve Growth Factors)
RN  - EC 3.1.3.- (microtubule-associated protein-2 phosphatase)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Brachial Plexus/enzymology/metabolism/*physiology
MH  - Cell Survival/physiology
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology/enzymology/physiology
MH  - Culture Media, Conditioned/metabolism/pharmacology
MH  - Hippocampus/physiology
MH  - Humans
MH  - Intracellular Fluid/enzymology/*physiology
MH  - MAP Kinase Signaling System/physiology
MH  - Macrophage Activation/*physiology
MH  - Macrophages/enzymology/*metabolism
MH  - Male
MH  - Mitochondria/metabolism/physiology
MH  - Nerve Growth Factors/*biosynthesis/physiology
MH  - Neurites/*physiology
MH  - Neurons/cytology/enzymology/physiology
MH  - Phosphoprotein Phosphatases/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Second Messenger Systems/*physiology
MH  - Synaptic Transmission/*physiology
MH  - Up-Regulation/physiology
EDAT- 2003/09/27 05:00
MHDA- 2004/01/06 05:00
CRDT- 2003/09/27 05:00
PHST- 2003/09/27 05:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/09/27 05:00 [entrez]
AID - S0165572803002534 [pii]
AID - 10.1016/s0165-5728(03)00253-4 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 Sep;142(1-2):112-29. doi: 10.1016/s0165-5728(03)00253-4.