PMID- 14514400
OWN - NLM
STAT- MEDLINE
DCOM- 20091208
LR  - 20030929
IS  - 1009-2587 (Print)
IS  - 1009-2587 (Linking)
VI  - 19
IP  - 4
DP  - 2003 Aug
TI  - [Optimal time for the administration of rhGH in severely burned 
      patients--analysis of the dynamic changes of IGF axis and blood sugar].
PG  - 213-5
AB  - OBJECTIVE: To investigate the effects of recombinant human growth hormone (rhGH) 
      on the changes in serum insulin-like growth factor-I (IGF-I), IGF binding protein 
      3 (IGFBP-3) and blood sugar in severely burned patients, so as to validate the 
      optimal time of rhGH administration. METHODS: Forty severely burned patients were 
      enrolled in the study and were randomly divided into control (C), treatment 1 
      (rhGH given from 7 - 9 PBD, T1) and treatment 2 (rhGH from 10 - 14 PBD, T2) 
      groups. The dynamic changes in serum IGF-I, IGFBP-3 and blood sugar on the 1, 3, 
      5, 7, 10, 14 and 21 PBDs in all 3 groups of burn patients were determined, 
      analyzed and compared with one another. RESULTS: The serum IGF-I, IGFBP-3 and 
      blood sugar levels in T1 and T2 groups were higher than those in C group after 
      the use of rhGH, especially the IGFBP-3 and blood sugar (P < 0.05). There was no 
      difference of all the indices between T1 and T2 groups. CONCLUSION: It might be 
      optimal to give rhGH to severely burned patients during 7-9 PBDs.
FAU - Han, Chun-mao
AU  - Han CM
AD  - Department of Burns, The Second Affiliated Hospital, Medical School of Zhejiang 
      University, Hangzhou, Zhejiang Province, PR China.
FAU - Xie, Wei-guo
AU  - Xie WG
FAU - Xu, Rong-feng
AU  - Xu RF
FAU - Chen, Guo-xian
AU  - Chen GX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Shao Shang Za Zhi
JT  - Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
JID - 100959418
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (Recombinant Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*drug effects/metabolism
MH  - Burns/blood/*drug therapy
MH  - Female
MH  - Human Growth Hormone/*administration & dosage/therapeutic use
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 1/*drug effects/metabolism
MH  - Insulin-Like Growth Factor I/*drug effects/metabolism
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins/*administration & dosage/therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2003/09/30 05:00
MHDA- 2009/12/16 06:00
CRDT- 2003/09/30 05:00
PHST- 2003/09/30 05:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2003/09/30 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Shao Shang Za Zhi. 2003 Aug;19(4):213-5.