PMID- 14514885
OWN - NLM
STAT- MEDLINE
DCOM- 20031204
LR  - 20240322
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 100
IP  - 21
DP  - 2003 Oct 14
TI  - Visual cortex is rescued from the effects of dark rearing by overexpression of 
      BDNF.
PG  - 12486-91
AB  - Visual deprivation such as dark rearing (DR) prolongs the critical period for 
      ocular dominance plasticity and retards the maturation of gamma-aminobutyric acid 
      (GABA)ergic inhibition in visual cortex. The molecular signals that mediate the 
      effects of DR on the development of visual cortex are not well defined. To test 
      the role of brain-derived neurotrophic factor (BDNF), we examined the effects of 
      DR in transgenic mice in which BDNF expression in visual cortex was uncoupled 
      from visual experience and remained elevated during DR. In dark-reared transgenic 
      mice, visual acuity, receptive field size of visual cortical neurons, critical 
      period for ocular dominance plasticity, and intracortical inhibition were 
      indistinguishable from those observed in light-reared mice. Therefore, BDNF 
      overexpression is sufficient for the development of aspects of visual cortex in 
      the absence of visual experience. These results suggest that reduced BDNF 
      expression contributes to retarded maturation of GABAergic inhibition and delayed 
      development of visual cortex during visual deprivation.
FAU - Gianfranceschi, Laura
AU  - Gianfranceschi L
AD  - Scuola Normale Superiore and Istituto di Neuroscienze del Consiglio Nazionale 
      delle Ricerche, 56100 Pisa, Italy.
FAU - Siciliano, Rosita
AU  - Siciliano R
FAU - Walls, Jennifer
AU  - Walls J
FAU - Morales, Bernardo
AU  - Morales B
FAU - Kirkwood, Alfredo
AU  - Kirkwood A
FAU - Huang, Z Josh
AU  - Huang ZJ
FAU - Tonegawa, Susumu
AU  - Tonegawa S
FAU - Maffei, Lamberto
AU  - Maffei L
LA  - eng
GR  - P50 MH058880/MH/NIMH NIH HHS/United States
GR  - R01 EY012124/EY/NEI NIH HHS/United States
GR  - MH 58880/MH/NIMH NIH HHS/United States
GR  - R01 EY 12124/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20030926
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/*genetics/*physiology
MH  - DNA/genetics
MH  - Darkness
MH  - Dominance, Ocular/physiology
MH  - Gene Expression
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Transgenic
MH  - RNA, Messenger/genetics/metabolism
MH  - Sensory Deprivation/*physiology
MH  - Visual Cortex/*growth & development/*physiology
MH  - gamma-Aminobutyric Acid/physiology
PMC - PMC218784
EDAT- 2003/09/30 05:00
MHDA- 2003/12/05 05:00
PMCR- 2004/04/14
CRDT- 2003/09/30 05:00
PHST- 2003/09/30 05:00 [pubmed]
PHST- 2003/12/05 05:00 [medline]
PHST- 2003/09/30 05:00 [entrez]
PHST- 2004/04/14 00:00 [pmc-release]
AID - 1934836100 [pii]
AID - 10012486 [pii]
AID - 10.1073/pnas.1934836100 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12486-91. doi: 
      10.1073/pnas.1934836100. Epub 2003 Sep 26.