PMID- 14515340
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20131121
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 50
IP  - 3
DP  - 2003 Dec 1
TI  - Early environment contributes to developmental disruption of MPFC after neonatal 
      ventral hippocampal lesions in rats.
PG  - 223-32
AB  - Using a putative animal model of schizophrenia, neonatal rat ventral hippocampal 
      (VH) lesions, combined with cross-fostering Lewis and Fisher rats, we previously 
      demonstrated that the postpubertal expression of amphetamine-induced 
      hyperlocomotion after lesioning depends on the early environment of the pups. 
      However, an important question that emerged from our studies was whether the 
      early environment leads to sparing of function within the VH or to the disruption 
      of another structure, such as the medial prefrontal cortex (MPFC). To answer this 
      question, we took advantage of the natural variation in maternal care of 
      Sprague-Dawley rat dams and separated them into high and low arched back nursing 
      (ABN) groups. Then, on postnatal day 7 (PD7) the pups from the two groups of dams 
      were lesioned in the VH. As a measure of VH function, the rats were tested in a 
      reference memory paradigm, which demonstrated that nVH-lesioned rats raised by 
      high or low ABN dams had pronounced deficits, suggesting that VH functions are 
      not fully spared. Next, the integrity of the MPFC was tested in a number of 
      paradigms in which MPFC function has been implicated. In all three paradigms a 
      similar result was found, that only lesioned rats raised by high ABN dams 
      displayed deficits, such as a lack of MPFC control of amphetamine-induced 
      locomotion, decreased working memory, and decreased anxiety. These results 
      suggest that the early environment does not affect the recovery of the VH to nVH 
      lesion. Rather, the early environment interacts with nVH lesions in such a way 
      that disrupts the development and function of MPFC.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Wood, Graham K
AU  - Wood GK
AD  - Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 
      Montreal, Quebec, Canada.
FAU - Quirion, Remi
AU  - Quirion R
FAU - Srivastava, Lalit K
AU  - Srivastava LK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Dopamine Agents)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Anxiety
MH  - Behavior, Animal/*physiology
MH  - Dopamine Agents/pharmacology
MH  - *Environment
MH  - Hippocampus/*physiology/surgery
MH  - Locomotion
MH  - Maternal Behavior
MH  - Memory
MH  - Prefrontal Cortex/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2003/09/30 05:00
MHDA- 2004/01/07 05:00
CRDT- 2003/09/30 05:00
PHST- 2003/09/30 05:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/09/30 05:00 [entrez]
AID - 10.1002/syn.10265 [doi]
PST - ppublish
SO  - Synapse. 2003 Dec 1;50(3):223-32. doi: 10.1002/syn.10265.