PMID- 14515741
OWN - NLM
STAT- MEDLINE
DCOM- 20031104
LR  - 20161124
IS  - 1341-8963 (Print)
IS  - 1341-8963 (Linking)
VI  - 38
IP  - 4
DP  - 2003 Aug
TI  - [Clinical significance of hepatic and splenic volumes measured by computed 
      tomography in patients with alcoholic liver cirrhosis].
PG  - 321-34
AB  - Hepatic and splenic volumes were measured by computed tomography in 43 patients 
      with alcoholic liver cirrhosis (AL-LC), 10 patients with HBs antigen-positive 
      liver cirrhosis (B-LC), 6 patients with HCV associated liver cirrhosis (C-LC) and 
      6 healthy subjects. Hepatic volume was significantly larger in the patients with 
      AL-LC than in those with B-LC, those with C-LC or healthy subjects. Hepatic 
      volume in patients with AL-LC was also significantly larger in the anti-HBc 
      antibody (anti-HBc)-negative patients than in the anti-HBc-positive patients. 
      This data suggests HBV occult infection may decrease hepatic volume. Hepatic 
      volume showed significantly positive correlations with serum levels of total 
      bilirubin (T. bil), gamma-GTP, type IV collagen levels, continuing alcohol intake 
      and Child-Pugh score, and also showed significant negative correlation with 
      cumulative alcohol intake and prothrombin time (PT). Splenic volume showed 
      significantly positive correlations with serum levels of T. bil and Child-Pugh 
      score, and also showed significantly negative correlations with serum albumin, 
      PT, platelet count and BCAA (branched chain amino acids)/tyrosine ratio. Stepwise 
      logistic regression analysis showed that enlarged hepatic volume, presence of 
      hepatocellular carcinoma and elevated serum gamma-GTP were independently 
      significant risk factors for the development of hepatic failure. Serial 
      determination of hepatic and splenic volume may be useful for the estimation of 
      liver function and prognosis in the patients with AL-LC.
FAU - Furushima, Hiroyuki
AU  - Furushima H
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      Daisan Hospital, Jikei University School of Medicine, 4-11-1, Izumihon-cho, 
      Komae, Tokyo 201-8601, Japan.
FAU - Ito, Shyuji
AU  - Ito S
FAU - Sakabe, Shunichi
AU  - Sakabe S
FAU - Kanai, Eichi
AU  - Kanai E
FAU - Yamauchi, Masayoshi
AU  - Yamauchi M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Arukoru Yakubutsu Igakkai Zasshi
JT  - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & 
      drug dependence
JID - 9612304
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Hepatitis B/complications/diagnostic imaging/pathology
MH  - Humans
MH  - Liver/*diagnostic imaging/*pathology
MH  - Liver Cirrhosis, Alcoholic/complications/*diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Spleen/*diagnostic imaging/*pathology
MH  - *Tomography, X-Ray Computed
EDAT- 2003/10/01 05:00
MHDA- 2003/11/05 05:00
CRDT- 2003/10/01 05:00
PHST- 2003/10/01 05:00 [pubmed]
PHST- 2003/11/05 05:00 [medline]
PHST- 2003/10/01 05:00 [entrez]
PST - ppublish
SO  - Nihon Arukoru Yakubutsu Igakkai Zasshi. 2003 Aug;38(4):321-34.