PMID- 14515783
OWN - NLM
STAT- MEDLINE
DCOM- 20050826
LR  - 20231213
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 38
IP  - 3
DP  - 2003 Jun
TI  - [Expression of the metastasis-associated gene 1 in laryngeal squamous cell 
      carcinoma: correlation with cervical lymph node metastasis].
PG  - 213-6
AB  - OBJECTIVE: The purpose of study was to examine the mRNA expression levels of the 
      metastasis-associated gene1 (MTA1) in laryngeal squamous cell carcinoma (LSCC), 
      so to evaluate its relationship with metastases. METHODS: Forty-eight surgically 
      resected primary LSCC (16 supraglotti laryngeal carcinomas with cervical lymph 
      node metastasis, 16 supraglotti laryngeal carcinomas with cervical lymph 
      node-negative metastasis, 16 glottic carcinoma with cervical lymph node-negative 
      metastasis) and 16 normal laryngeal mucosa was examined for mRNA expression of 
      MTA1 by reverse transcription-polymerase chain reaction(RT-PCR). RESULTS: The 
      frequency of MTA1 mRNA positive expression in 16 LSCC with cervical lymph node 
      metastasis was 100%, but no expression of MTA1 mRNA was observed in other LSCC 
      with cervical lymph node-negative metastasis (16 supraglotti laryngeal carcinomas 
      and 16 glottic carcinoma) and 16 normal laryngeal mucosa. CONCLUSION: MTA1 gene 
      is strongly related to cervical lymph node metastasis of LSCC, and may serve as a 
      early diagnosis indicator.
FAU - Tang, Qiao-fei
AU  - Tang QF
AD  - Department of Otorhinolaryngology, First Clinical College, Chinese Medical 
      University, Shenyang 110001, China. javawriter@163.com
FAU - Ji, Wen-yue
AU  - Ji WY
FAU - Pan, Zi-min
AU  - Pan ZM
FAU - Zheng, Yan
AU  - Zheng Y
FAU - Guan, Chao
AU  - Guan C
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (MTA1 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/metabolism/*secondary
MH  - Female
MH  - Histone Deacetylases/*biosynthesis/genetics
MH  - Humans
MH  - Laryngeal Neoplasms/metabolism/*pathology
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis/genetics
MH  - Male
MH  - Middle Aged
MH  - Neck
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Repressor Proteins/*biosynthesis/genetics
MH  - Trans-Activators
EDAT- 2003/10/01 05:00
MHDA- 2005/08/27 09:00
CRDT- 2003/10/01 05:00
PHST- 2003/10/01 05:00 [pubmed]
PHST- 2005/08/27 09:00 [medline]
PHST- 2003/10/01 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Jun;38(3):213-6.