PMID- 14516318
OWN - NLM
STAT- MEDLINE
DCOM- 20040720
LR  - 20190916
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 53
IP  - 10
DP  - 2003 Oct
TI  - Primary carcinoid tumor of the testis: Immunohistochemical, ultrastructural and 
      FISH analysis with review of the literature.
PG  - 680-5
AB  - Primary carcinoid tumor of the testis only accounts for 0.2% of all carcinoid 
      tumors in Japan. The clinicopathological features, including differences between 
      Japanese and Europe/United States (Eur/US) series', which are known in ovarian 
      carcinoids, have not yet been sufficiently recognized. In the present study, five 
      testicular carcinoids from various clinicopathological viewpoints were analyzed, 
      with a review of the literature. All 15 cases in Japan, including 10 previously 
      reported, were insular carcinoids. Three of the 15 cases (20%) were associated 
      with a teratoma. Serotonin production was confirmed in at least 10 cases (five 
      cases in the present study and five cases in previous studies), but carcinoid 
      syndrome was present in only two cases. Three of the 15 cases (20%) showed 
      distant metastases, and the tumors that metastasized were larger than those that 
      did not. These features were almost similar to those observed in the Eur/US 
      series. Three pure carcinoids were also studied for the number of sex chromosomes 
      by fluorescence in situ hybridization (FISH). They did not show a significant 
      numerical abnormality of the X chromosome, which is common in testicular germ 
      cell tumors. Therefore, the genetic background of pure carcinoids might be 
      different from that of common germ cell tumors.
FAU - Kato, Noriko
AU  - Kato N
AD  - Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan. 
      nkato@med.id.yamagata-u.ac.jp
FAU - Motoyama, Teiichi
AU  - Motoyama T
FAU - Kameda, Noriaki
AU  - Kameda N
FAU - Hiruta, Nobuaki
AU  - Hiruta N
FAU - Emura, Iwao
AU  - Emura I
FAU - Hasegawa, Go
AU  - Hasegawa G
FAU - Murata, Tetsuya
AU  - Murata T
FAU - Kimura, Mikihiko
AU  - Kimura M
FAU - Tsuda, Hitoshi
AU  - Tsuda H
FAU - Ishihara, Tokuhiro
AU  - Ishihara T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Biomarkers, Tumor)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoid Tumor/chemistry/genetics/*pathology
MH  - Chromosomes, Human, X
MH  - Cytoplasmic Granules/ultrastructure
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Serotonin/analysis
MH  - Sex Chromosome Aberrations
MH  - Testicular Neoplasms/chemistry/genetics/*pathology
EDAT- 2003/10/01 05:00
MHDA- 2004/07/21 05:00
CRDT- 2003/10/01 05:00
PHST- 2003/10/01 05:00 [pubmed]
PHST- 2004/07/21 05:00 [medline]
PHST- 2003/10/01 05:00 [entrez]
AID - 1535 [pii]
AID - 10.1046/j.1440-1827.2003.01535.x [doi]
PST - ppublish
SO  - Pathol Int. 2003 Oct;53(10):680-5. doi: 10.1046/j.1440-1827.2003.01535.x.