PMID- 14517446
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20031009
LR  - 20191108
IS  - 0969-6970 (Print)
IS  - 0969-6970 (Linking)
VI  - 3
IP  - 1
DP  - 1999
TI  - Regulation of angiogenesis and endothelial cell motility by matrix-bound 
      fibroblasts.
PG  - 69-76
AB  - This study sought to examine the effect of matrix-bound fibroblasts on 
      angiogenesis and endothelial cell motility. Promotion of angiogenesis by 
      matrix-bound fibroblasts was assessed using rat aortic ring and endothelial tube 
      formation assays. Enhancement of human endothelial cell motility by matrix-bound 
      fibroblasts was assessed using cytodex-2 bead and colloidal gold phagokinetic 
      motility assays. Antibody to hepatocyte growth factor/scatter factor (HGF/SF) but 
      not vascular endothelial growth factor (VEGf) decreased fibroblast-enhanced 
      motility of endothelial cells. The promotion of tube formation by matrix-bound 
      fibroblasts was neutralised with antibodies to HGF/SF and VEGf, both known 
      promoters of angiogenesis. HGF/SF presence was detected by ELISA; whilst the 
      presence of VEGf was detected by Western blotting. These data show that 
      matrix-embedded fibroblasts regulate the motility of vascular endothelial cells 
      and enhance angiogenesis, an effect partly attributed to production of 
      angiogenesis-promoting cytokines HGF/SF and/or VEGf.
FAU - Martin, T A
AU  - Martin TA
AD  - Wound Healing Research Unit, University of Wales College of Medicine, Cardiff, 
      UK. martinta1@cf.ac.uk
FAU - Harding, K G
AU  - Harding KG
FAU - Jiang, W G
AU  - Jiang WG
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Angiogenesis
JT  - Angiogenesis
JID - 9814575
EDAT- 2003/10/01 05:00
MHDA- 2003/10/01 05:01
CRDT- 2003/10/01 05:00
PHST- 2003/10/01 05:00 [pubmed]
PHST- 2003/10/01 05:01 [medline]
PHST- 2003/10/01 05:00 [entrez]
AID - 239130 [pii]
AID - 10.1023/a:1009004212357 [doi]
PST - ppublish
SO  - Angiogenesis. 1999;3(1):69-76. doi: 10.1023/a:1009004212357.