PMID- 14519277
OWN - NLM
STAT- MEDLINE
DCOM- 20040213
LR  - 20190916
IS  - 0300-8932 (Print)
IS  - 0300-8932 (Linking)
VI  - 56
IP  - 9
DP  - 2003 Sep
TI  - [Heart malformations in children with Down syndrome].
PG  - 894-9
AB  - INTRODUCTION AND OBJECTIVES: A longitudinal, retrospective, observational 
      descriptive study was done at the National Institute of Pediatrics in Mexico City 
      to determine the incidence, type of heart disease and clinical course in patients 
      with Down syndrome (DS), and to compare the findings with data from other 
      countries. Down syndrome is a disease caused by trisomy of chromosome 21. The 
      frequency of presentation in one in 650 live births. Frequency in the general 
      population is about 1%. Cardiac malformation is the main cause of mortality in 
      the first 2 years of life. PATIENTS AND METHOD: In a 5-year period 275 patients 
      (aged neonate to 13 years) were diagnosed with DS. Diagnosis was based on 
      echocardiogram, catheterization, genetics, surgical exploration or necropsy. Age, 
      sex, clinical manifestations, mother's age, type of heart defect were recorded. 
      RESULTS: Of the 275 children with DS, 160 had congenital heart disease. The most 
      frequent cardiopathies were interauricular septal defect (IASD), interventricular 
      septal defect (IVSD) and patent ductus arteriousus (PDA) (90%). In contrast to 
      the data from other countries, only 14 patients (8%) had atrioventricular septal 
      defect (AVSD). Twenty-five patients died (15%) from sepsis and cardiogenic shock. 
      CONCLUSIONS: At our institute 58% of the children with DS had congenital heart 
      malformation. The most frequent cardiopathies were different from those reported 
      in other countries.
FAU - de Rubens Figueroa, Jesus
AU  - de Rubens Figueroa J
AD  - Instituto Nacional de Pediatria. Mexico, D.F. Mexico. derubens@hotmail.com
FAU - del Pozzo Magana, Blanca
AU  - del Pozzo Magana B
FAU - Pablos Hach, Jose L
AU  - Pablos Hach JL
FAU - Calderon Jimenez, Claudia
AU  - Calderon Jimenez C
FAU - Castrejon Urbina, Rocio
AU  - Castrejon Urbina R
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Malformaciones cardiacas en los ninos con sindrome de Down.
PL  - Spain
TA  - Rev Esp Cardiol
JT  - Revista espanola de cardiologia
JID - 0404277
SB  - IM
CIN - Rev Esp Cardiol. 2004 May;57(5):482; author reply 482. PMID: 15151784
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Down Syndrome/*complications
MH  - Female
MH  - Heart Defects, Congenital/*complications/epidemiology
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Longitudinal Studies
MH  - Male
MH  - Retrospective Studies
RF  - 29
EDAT- 2003/10/02 05:00
MHDA- 2004/02/14 05:00
CRDT- 2003/10/02 05:00
PHST- 2003/10/02 05:00 [pubmed]
PHST- 2004/02/14 05:00 [medline]
PHST- 2003/10/02 05:00 [entrez]
AID - 13051617 [pii]
AID - 10.1016/s0300-8932(03)76978-4 [doi]
PST - ppublish
SO  - Rev Esp Cardiol. 2003 Sep;56(9):894-9. doi: 10.1016/s0300-8932(03)76978-4.