PMID- 14519304
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20190916
IS  - 1695-4033 (Print)
IS  - 1695-4033 (Linking)
VI  - 59
IP  - 4
DP  - 2003 Oct
TI  - [The role of molecular genetics in childhood cancer].
PG  - 334-44
AB  - In the last few years molecular genetic studies of childhood cancer have acquired 
      great importance. Advances in these techniques have increased knowledge of the 
      various genes involved in tumoral development. Genetic alterations can occur in 
      three large groups of genes: oncogenes, tumor suppressor genes, and DNA repair 
      genes. Cytogenetic analyses (karyotyping) are complemented by various molecular 
      techniques, such as fluorescence in situ hybridization (FISH), reverse 
      transcriptase-polymerase chain reaction (RT-PCR) and spectral karyotyping (SKY). 
      These are the most reliable techniques and improve the sensitivity of 
      karyotyping. The present article reviews the most representative and best 
      characterized genes involved in the molecular etiology of childhood cancer, both 
      hematologic malignancies (leukemia and lymphoma) and solid tumors (brain tumors, 
      neuroblastoma, Wilms' tumor, hepatoblastoma, rhabdomyosarcoma, Ewing's sarcoma 
      and retinoblastoma). Molecular techniques have enabled more precise diagnosis as 
      well as identification of new prognostic factors and the development of more 
      effective treatments. These techniques can also be useful in identifying minimal 
      residual disease during and after treatment for leukemias, neuroblastomas and 
      sarcomas, with the aim of predicting recurrence.
FAU - Lopez Almaraz, R
AU  - Lopez Almaraz R
AD  - Servicio de Pediatria, Unidad de Oncohematologia Pediatrica, Hospital 
      Universitario de Canarias, La Laguna, Tenerife, Espana. ritxil@comtf.es
FAU - Montesdeoca Melian, A
AU  - Montesdeoca Melian A
FAU - Rodriguez Luis, J
AU  - Rodriguez Luis J
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Papel de la genetica molecular en el cancer infantil.
PL  - Spain
TA  - An Pediatr (Barc)
JT  - Anales de pediatria (Barcelona, Spain : 2003)
JID - 101162596
SB  - IM
MH  - Child
MH  - Forecasting
MH  - Humans
MH  - Molecular Biology/trends
MH  - Neoplasms/*diagnosis/*genetics
RF  - 67
EDAT- 2003/10/02 05:00
MHDA- 2004/01/07 05:00
CRDT- 2003/10/02 05:00
PHST- 2003/10/02 05:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/10/02 05:00 [entrez]
AID - 13051317 [pii]
AID - 10.1016/s1695-4033(03)78192-2 [doi]
PST - ppublish
SO  - An Pediatr (Barc). 2003 Oct;59(4):334-44. doi: 10.1016/s1695-4033(03)78192-2.