PMID- 14519415
OWN - NLM
STAT- MEDLINE
DCOM- 20040811
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 477
IP  - 2
DP  - 2003 Sep 12
TI  - Effects of alpha(1)-adrenoceptors and muscarinic cholinoceptors on water intake 
      in rats.
PG  - 123-7
AB  - The present study investigated the effects of alpha(1)-adrenoceptors and 
      muscarinic cholinoceptors on water intake in adult male rats. 
      Intracerebroventricular (i.c.v.) injections were carried out in all experiments 
      after 24-h deprivation of water. After deprivation, the volume of consumed water 
      was measured for 1 h. Administration of pilocarpine, a muscarinic cholinoceptor 
      agonist (0.5-1 microg/rat), and prazosin, the alpha(1)-adrenoceptors antagonist 
      (2 microg/rat), increased, while scopolamine, a muscarinic cholinoceptor 
      antagonist (5-10 microg/rat), and phenylephrine, an alpha(1)-adrenoceptor agonist 
      (30 microg/rat), decreased water intake in rats. The activation of muscarinic 
      cholinoceptors by pilocarpine attenuated the inhibitory effect induced by 
      phenylephrine. Blockade of muscarinic cholinoceptors did not change the 
      phenylephrine-induced response. Pretreatment with prazosin decreased the 
      pilocarpine-induced response. However, pharmacological blockade of muscarinic 
      cholinoceptors by scopolamine decreased the prazosin-induced effect on water 
      intake. It is concluded that muscarinic cholinoceptors and alpha(1)-adrenoceptors 
      may interact on water intake.
FAU - Oryan, Shahrbanoo
AU  - Oryan S
AD  - Department of Biology, Science Faculty, Teacher Training University, Tehran, 
      Iran.
FAU - Eidi, Maryam
AU  - Eidi M
FAU - Eidi, Akram
AU  - Eidi A
FAU - Kohanrooz, Behrooz
AU  - Kohanrooz B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Adrenergic alpha-1 Receptor Agonists)
RN  - 0 (Adrenergic alpha-1 Receptor Antagonists)
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Muscarinic Agonists)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 0 (Receptors, Muscarinic)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - 1WS297W6MV (Phenylephrine)
RN  - DL48G20X8X (Scopolamine)
RN  - XM03YJ541D (Prazosin)
SB  - IM
MH  - Adrenergic alpha-1 Receptor Agonists
MH  - Adrenergic alpha-1 Receptor Antagonists
MH  - Adrenergic alpha-Agonists/administration & dosage/pharmacology
MH  - Adrenergic alpha-Antagonists/administration & dosage/pharmacology
MH  - Animals
MH  - Drinking/*drug effects/physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Muscarinic Agonists/administration & dosage/pharmacology
MH  - Muscarinic Antagonists/administration & dosage/pharmacology
MH  - Phenylephrine/administration & dosage/pharmacology
MH  - Pilocarpine/administration & dosage/pharmacology
MH  - Prazosin/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adrenergic, alpha-1/*physiology
MH  - Receptors, Muscarinic/drug effects/*physiology
MH  - Scopolamine/administration & dosage/pharmacology
EDAT- 2003/10/02 05:00
MHDA- 2004/08/12 05:00
CRDT- 2003/10/02 05:00
PHST- 2003/10/02 05:00 [pubmed]
PHST- 2004/08/12 05:00 [medline]
PHST- 2003/10/02 05:00 [entrez]
AID - S0014299903021812 [pii]
AID - 10.1016/j.ejphar.2003.07.002 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2003 Sep 12;477(2):123-7. doi: 10.1016/j.ejphar.2003.07.002.