PMID- 14519610
OWN - NLM
STAT- MEDLINE
DCOM- 20031204
LR  - 20220309
IS  - 0007-1250 (Print)
IS  - 0007-1250 (Linking)
VI  - 183
DP  - 2003 Oct
TI  - Estimating psychological treatment effects from a randomised controlled trial 
      with both non-compliance and loss to follow-up.
PG  - 323-31
AB  - BACKGROUND: The Outcomes of Depression International Network (ODIN) trial 
      evaluated the effect of two psychological interventions for the treatment of 
      depression in primary care. Only about half of the patients in the treatment arm 
      complied with the offer of treatment, prompting the question:'what was the effect 
      of treatment in those patients who actually received it?' AIMS: To illustrate the 
      estimation of the effect of receipt of treatment in a randomised controlled trial 
      subject to non-compliance and loss to follow-up. METHOD: We estimated the 
      complier average causal effect (CACE) of treatment. RESULTS: In the ODIN trial 
      the effect of receipt of psychological intervention (an average of about 4 points 
      on the Beck Depression Inventory) is about twice that of offering it. 
      CONCLUSIONS: The statistical analysis of the results of a clinical trial subject 
      to non-compliance to allocated treatment is now reasonably straightforward 
      through estimation of a CACE and investigators should be encouraged to present 
      the results of analyses of this type as a routine component of a trial report.
FAU - Dunn, G
AU  - Dunn G
AD  - Biostatistics Group, School of Epidemiology & Health Sciences, University of 
      Manchester, UK. g.dunn@man.ac.uk
FAU - Maracy, M
AU  - Maracy M
FAU - Dowrick, C
AU  - Dowrick C
FAU - Ayuso-Mateos, J L
AU  - Ayuso-Mateos JL
FAU - Dalgard, O S
AU  - Dalgard OS
FAU - Page, H
AU  - Page H
FAU - Lehtinen, V
AU  - Lehtinen V
FAU - Casey, P
AU  - Casey P
FAU - Wilkinson, C
AU  - Wilkinson C
FAU - Vazquez-Barquero, J L
AU  - Vazquez-Barquero JL
FAU - Wilkinson, G
AU  - Wilkinson G
CN  - ODIN group
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
SB  - IM
MH  - Data Interpretation, Statistical
MH  - Depressive Disorder/*therapy
MH  - Humans
MH  - Patient Participation
MH  - Psychotherapy/*methods
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
MH  - Treatment Refusal
EDAT- 2003/10/02 05:00
MHDA- 2003/12/05 05:00
CRDT- 2003/10/02 05:00
PHST- 2003/10/02 05:00 [pubmed]
PHST- 2003/12/05 05:00 [medline]
PHST- 2003/10/02 05:00 [entrez]
AID - S0007125000163299 [pii]
AID - 10.1192/bjp.183.4.323 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2003 Oct;183:323-31. doi: 10.1192/bjp.183.4.323.