PMID- 14520509
OWN - NLM
STAT- MEDLINE
DCOM- 20040928
LR  - 20161124
IS  - 0340-5761 (Print)
IS  - 0340-5761 (Linking)
VI  - 78
IP  - 2
DP  - 2004 Feb
TI  - Lack of maternal dietary exposure effects of bisphenol A and nonylphenol during 
      the critical period for brain sexual differentiation on the 
      reproductive/endocrine systems in later life.
PG  - 97-105
AB  - Two potential endocrine-disrupting chemicals, bisphenol A (BPA) and nonylphenol 
      (NP), were assessed for their long-lasting effects on endocrine/reproductive 
      systems following transplacental and lactational exposure to rat offspring during 
      a time-window that included the critical period for brain sexual differentiation. 
      Each chemical was mixed with diet at concentrations of 60, 600 and 3000 ppm and 
      was provided to maternal Sprague-Dawley rats from gestational day (GD) 15 to 
      postnatal day (PND) 10. Ethinylestradiol (EE) at 0.5 ppm was used as an 
      estrogenic reference drug. During pregnancy and lactation, including the exposure 
      period, a soy-free rodent diet was provided to eliminate possible modification of 
      the study results by plant-derived phytoestrogens. Effects on 
      endocrine/reproductive systems were evaluated by examining the anogenital 
      distance, organ weights before puberty, onset of puberty, estrous cyclicity, and 
      organ weights and histopathology of adult endocrine organs (at 11 weeks of age), 
      as well as the volume of the sexually dimorphic nucleus of preoptic area. Both NP 
      and BPA, at high doses, caused decreases in maternal body weights and retardation 
      of offspring growth, but neither affected any of the endocrine/reproductive 
      endpoints of offspring, whereas EE induced irreversible changes in estrous 
      cyclicity and histopathology of ovaries and uterus of adult females. The results 
      indicated that maternal dietary exposure to NP or BPA at concentrations up to 
      3000 ppm from GD 15 through PND 10 do not exert any apparent adverse effects on 
      the endocrine/reproductive systems of offspring.
FAU - Takagi, Hironori
AU  - Takagi H
AD  - Division of Pathology, National Institute of Health Sciences, 158-8501, Tokyo, 
      Japan.
FAU - Shibutani, Makoto
AU  - Shibutani M
FAU - Masutomi, Naoya
AU  - Masutomi N
FAU - Uneyama, Chikako
AU  - Uneyama C
FAU - Takahashi, Noriyuki
AU  - Takahashi N
FAU - Mitsumori, Kunitoshi
AU  - Mitsumori K
FAU - Hirose, Masao
AU  - Hirose M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031001
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 79F6A2ILP5 (nonylphenol)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Benzhydryl Compounds
MH  - Brain/drug effects/embryology/growth & development
MH  - Diet
MH  - Dose-Response Relationship, Drug
MH  - Endocrine System/*drug effects/growth & development/pathology
MH  - Estrogens, Non-Steroidal/administration & dosage/*toxicity
MH  - Female
MH  - Genitalia/*drug effects/growth & development/pathology
MH  - Lactation
MH  - Maternal Exposure/*adverse effects
MH  - Phenols/administration & dosage/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sex Characteristics
MH  - Time Factors
EDAT- 2003/10/02 05:00
MHDA- 2004/09/29 05:00
CRDT- 2003/10/02 05:00
PHST- 2003/03/07 00:00 [received]
PHST- 2003/08/19 00:00 [accepted]
PHST- 2003/10/02 05:00 [pubmed]
PHST- 2004/09/29 05:00 [medline]
PHST- 2003/10/02 05:00 [entrez]
AID - 10.1007/s00204-003-0517-0 [doi]
PST - ppublish
SO  - Arch Toxicol. 2004 Feb;78(2):97-105. doi: 10.1007/s00204-003-0517-0. Epub 2003 
      Oct 1.