PMID- 14521993
OWN - NLM
STAT- MEDLINE
DCOM- 20031219
LR  - 20191210
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 121
IP  - 2
DP  - 2003
TI  - Learning deficits in forebrain-restricted brain-derived neurotrophic factor 
      mutant mice.
PG  - 341-54
AB  - Brain-derived neurotrophic factor (BDNF) participates in synaptic plasticity and 
      the adaptive changes in the strength of communication between neurons thought to 
      underlie aspects of behavioral adaptation. By selectively deleting BDNF from the 
      forebrain of mice using the Cre site-specific DNA recombinase, we were able to 
      study the requirements for BDNF in behaviors such as learning and anxiety. 
      Early-onset forebrain-restricted BDNF mutant mice (Emx-BDNF(KO)) that develop in 
      the absence of BDNF in the dorsal cortex, hippocampus, and parts of the ventral 
      cortex and amygdala failed to learn the Morris Water Maze task, a 
      hippocampal-dependent visuo-spatial learning task. Freezing during all phases of 
      cued-contextual fear conditioning, a behavioral task designed to study 
      hippocampal-dependent associative learning, was enhanced. These mice learned a 
      brightness discrimination task well but were impaired in a more difficult pattern 
      discrimination task. Emx-BDNF(KO) mice did not exhibit altered sensory processing 
      and gating, as measured by the acoustic startle response or prepulse inhibition 
      of the startle response. Although they were less active in an open-field arena, 
      they did not show alterations in anxiety, as measured in the elevated-plus maze, 
      black-white chamber or mirrored chamber tasks. Combined, these data indicate that 
      although an absence of forebrain BDNF does not disrupt acoustic sensory 
      processing or alter baseline anxiety, specific forms of learning are severely 
      impaired.
FAU - Gorski, J A
AU  - Gorski JA
AD  - Department of Molecular, Cellular & Developmental Biology, University of Colorado 
      at Boulder, Boulder, CO 80309, USA.
FAU - Balogh, S A
AU  - Balogh SA
FAU - Wehner, J M
AU  - Wehner JM
FAU - Jones, K R
AU  - Jones KR
LA  - eng
GR  - MH-16880/MH/NIMH NIH HHS/United States
GR  - MH-53668/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (empty spiracles homeobox proteins)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Anxiety
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism
MH  - Conditioning, Classical
MH  - Discrimination Learning
MH  - Fear
MH  - Genotype
MH  - Homeodomain Proteins/genetics
MH  - Learning Disabilities/*physiopathology
MH  - Maze Learning
MH  - Memory Disorders
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout/metabolism/physiology
MH  - Motor Activity
MH  - Prosencephalon/*metabolism
MH  - Reaction Time
MH  - Reflex, Startle/physiology
MH  - Time Factors
MH  - Transcription Factors
EDAT- 2003/10/03 05:00
MHDA- 2003/12/20 05:00
CRDT- 2003/10/03 05:00
PHST- 2003/10/03 05:00 [pubmed]
PHST- 2003/12/20 05:00 [medline]
PHST- 2003/10/03 05:00 [entrez]
AID - S0306452203004263 [pii]
AID - 10.1016/s0306-4522(03)00426-3 [doi]
PST - ppublish
SO  - Neuroscience. 2003;121(2):341-54. doi: 10.1016/s0306-4522(03)00426-3.