PMID- 14522092
OWN - NLM
STAT- MEDLINE
DCOM- 20040527
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 10
DP  - 2003 Oct
TI  - No evidence of type 1 diabetes susceptibility genes in the region centromeric of 
      the HLA complex.
PG  - 951-9
AB  - There is strong evidence that DQB1, DQA1, and DRB1 alleles are not the only 
      contributors to the human leukocyte antigen (HLA) linked type 1 diabetes (T1D) 
      predisposition. Although the HLA complex is much studied for disease association, 
      little is known about the neighboring centromeric region. We have previously 
      found suggestive association on DQ2-DR3 haplotypes for marker D6S291, located 
      3.6-Mb centromeric of HLA-DQB1. This region on human chromosome 6 is syntenic to 
      a part of the region adjacent to the mouse major histocompatibility complex (MHC) 
      on chromosome 17, which has been suggested to harbor a susceptibility gene in 
      mouse (Idd16). To evaluate a possible role of the region centromeric of HLA-DQB1 
      in human T1D, we have scanned the region with nine microsatellite markers in 267 
      T1D families from five different populations. Our results indicate that the 
      characteristic strong linkage disequilibrium in the HLA complex does not extend 
      into this region. Furthermore, we did not detect any consistent T1D association 
      for the markers analyzed in the study. In conclusion, our data argue against the 
      presence of any strong genetic susceptibility factors for T1D in the region 
      centromeric of the HLA complex.
FAU - Johansson, Stefan
AU  - Johansson S
AD  - Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway. 
      Stefan.johansson@pedi.uib.no
FAU - Lie, Benedicte A
AU  - Lie BA
FAU - Cambon-Thomsen, Anne
AU  - Cambon-Thomsen A
FAU - Pociot, Flemming
AU  - Pociot F
FAU - Nerup, Jorn
AU  - Nerup J
FAU - Kockum, Ingrid
AU  - Kockum I
FAU - Thorsby, Erik
AU  - Thorsby E
FAU - Undlien, Dag E
AU  - Undlien DE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Alleles
MH  - Diabetes Mellitus, Type 1/genetics/*immunology/metabolism
MH  - *Genetic Predisposition to Disease
MH  - Histocompatibility Antigens/*genetics/immunology/metabolism
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Microsatellite Repeats
EDAT- 2003/10/03 05:00
MHDA- 2004/05/28 05:00
CRDT- 2003/10/03 05:00
PHST- 2003/10/03 05:00 [pubmed]
PHST- 2004/05/28 05:00 [medline]
PHST- 2003/10/03 05:00 [entrez]
AID - S0198885903001721 [pii]
AID - 10.1016/s0198-8859(03)00172-1 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Oct;64(10):951-9. doi: 10.1016/s0198-8859(03)00172-1.