PMID- 14526262
OWN - NLM
STAT- MEDLINE
DCOM- 20031224
LR  - 20191108
IS  - 1262-3636 (Print)
IS  - 1262-3636 (Linking)
VI  - 29
IP  - 4 Pt 1
DP  - 2003 Sep
TI  - Reproducibility of plasma insulin kinetics during intraperitoneal insulin 
      treatment by programmable pumps.
PG  - 344-8
AB  - OBJECTIVE: To study the reproducibility of plasma insulin kinetics during 
      intraperitoneal (IP) insulin therapy using an implanted programmable pump in 
      patients with type 1, insulin dependent, diabetes mellitus (IDDM). RESEARCH 
      DESIGN AND METHODS: In a group of ten type 1 IDDM patients beginning chronic IP 
      insulin treatment with an implanted pump, plasma free insulin profiles were 
      determined from 12: 00 am to 12: 30 pm on two separate test days, one month 
      apart. Anti-insulin antibody (AIA) levels were measured on each test day. 
      RESULTS: From test day 1 to test day 2, no difference was observed in morning 
      fasting free insulin levels (m +/- SD): 9.7 +/- 5.4 mU/L versus 9.8 +/- 5.3 mU/L, 
      insulin peak values: 19.1 +/- 17 mU/L versus 20.8 +/- 9.9 mU/L, time to peak: 40 
      +/- 15 versus 42.8 +/- 16 minutes or post-bolus area under the plasma free 
      insulin curve (AUC): 40.7 +/- 29 mU/L.h versus 45.5 +/- 29 mU/L.h. The 
      intrapatient coefficient of variation was 14.4 +/- 13% for insulin peaks and 16.9 
      +/- 9.2% for post-bolus AUC. A significant increase in AIA levels (m +/- SD) was 
      observed from 16.5 +/- 18% on test day 1 to 28.1 +/- 28% on test day 2. 
      CONCLUSIONS: The reproducibility of plasma free insulin profiles is highly 
      satisfactory during insulin delivery by the IP route using an implanted device.
FAU - Schaepelynck Belicar, P
AU  - Schaepelynck Belicar P
AD  - Service de Nutrition-Endocrinologie-Maladies Metaboliques, Hopital Timone 
      Adultes, Marseille, France. pauline.schaepelynck@mail.ap-hm.fr
FAU - Vague, P
AU  - Vague P
FAU - Lassmann-Vague, V
AU  - Lassmann-Vague V
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Insulin)
RN  - 0 (Insulin Antibodies)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Area Under Curve
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 1/*blood/*drug therapy/immunology
MH  - Humans
MH  - Insulin/*blood/pharmacokinetics/*therapeutic use
MH  - Insulin Antibodies/blood
MH  - *Insulin Infusion Systems
MH  - Radioimmunoassay
MH  - Reproducibility of Results
EDAT- 2003/10/04 05:00
MHDA- 2003/12/25 05:00
CRDT- 2003/10/04 05:00
PHST- 2003/10/04 05:00 [pubmed]
PHST- 2003/12/25 05:00 [medline]
PHST- 2003/10/04 05:00 [entrez]
AID - MDOI-DM-09-2003-29-4C1-1262-3636-101019-ART2 [pii]
AID - 10.1016/s1262-3636(07)70045-9 [doi]
PST - ppublish
SO  - Diabetes Metab. 2003 Sep;29(4 Pt 1):344-8. doi: 10.1016/s1262-3636(07)70045-9.