PMID- 14527590
OWN - NLM
STAT- MEDLINE
DCOM- 20031121
LR  - 20191108
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 20
IP  - 1
DP  - 2003 Sep
TI  - Brain activity during automatic semantic priming revealed by event-related 
      functional magnetic resonance imaging.
PG  - 302-10
AB  - Semantic priming occurs when a subject is faster in recognising a target word 
      when it is preceded by a related word compared to an unrelated word. The effect 
      is attributed to automatic or controlled processing mechanisms elicited by short 
      or long interstimulus intervals (ISIs) between primes and targets. We employed 
      event-related functional magnetic resonance imaging (fMRI) to investigate blood 
      oxygen level dependent (BOLD) responses associated with automatic semantic 
      priming using an experimental design identical to that used in standard 
      behavioural priming tasks. Prime-target semantic strength was manipulated by 
      using lexical ambiguity primes (e.g., bank) and target words related to dominant 
      or subordinate meaning of the ambiguity. Subjects made speeded lexical decisions 
      (word/nonword) on dominant related, subordinate related, and unrelated word pairs 
      presented randomly with a short ISI. The major finding was a pattern of reduced 
      activity in middle temporal and inferior prefrontal regions for dominant versus 
      unrelated and subordinate versus unrelated comparisons, respectively. These 
      findings are consistent with both a dual process model of semantic priming and 
      recent repetition priming data that suggest that reductions in BOLD responses 
      represent neural priming associated with automatic semantic activation and 
      implicate the left middle temporal cortex and inferior prefrontal cortex in more 
      automatic aspects of semantic processing.
FAU - Copland, David A
AU  - Copland DA
AD  - Centre for Research in Language Processing and Linguistics, Department of Speech 
      Pathology and Audiology, The University of Queensland, Queensland, Australia. 
      d.copland@uq.edu.au
FAU - de Zubicaray, Greig I
AU  - de Zubicaray GI
FAU - McMahon, Katie
AU  - McMahon K
FAU - Wilson, Stephen J
AU  - Wilson SJ
FAU - Eastburn, Matt
AU  - Eastburn M
FAU - Chenery, Helen J
AU  - Chenery HJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Chemistry/physiology
MH  - Brain Mapping
MH  - *Cues
MH  - Dominance, Cerebral/physiology
MH  - Evoked Potentials/physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Oxygen Consumption
MH  - Prefrontal Cortex/physiology
MH  - Reading
MH  - Temporal Lobe/physiology
EDAT- 2003/10/07 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/07 05:00
PHST- 2003/10/07 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/07 05:00 [entrez]
AID - S1053811903002799 [pii]
AID - 10.1016/s1053-8119(03)00279-9 [doi]
PST - ppublish
SO  - Neuroimage. 2003 Sep;20(1):302-10. doi: 10.1016/s1053-8119(03)00279-9.