PMID- 14527717
OWN - NLM
STAT- MEDLINE
DCOM- 20031125
LR  - 20190708
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 314
DP  - 2003 Sep 18
TI  - Identification of the Drosophila progenitor of mammalian Kruppel-like factors 6 
      and 7 and a determinant of fly development.
PG  - 55-62
AB  - The Kruppel-like transcription factors (KLFs) represent a family of 15 different 
      zinc finger proteins of the C(2)H(2) type that are involved in vertebrate 
      development and which control cell proliferation, growth and differentiation. 
      Structural-functional considerations have segregated KLF6 and KLF7 into a 
      phylogenetically distinct group. Here we report the identification of Luna, the 
      Drosophila progenitor of the mammalian KLF6/KLF7 group. This conclusion is based 
      on the near sequence identity, as well as the comparable location of the 
      DNA-binding domains and nuclear localization signals of the insect and mammalian 
      proteins. The homology extends to the composition and function of the 
      amino-terminal segment of Luna which, similarly to the mammalian counterparts, 
      stimulates transcription in a reporter gene assay. We also present preliminary in 
      vivo evidence of Luna involvement in embryonic development and cell 
      differentiation. First, luna RNA interference and luna overexpression during 
      early Drosophila embryogenesis leads to developmental arrest at different 
      embryonic stages. Second, targeted perturbation of luna expression in the forming 
      compound eye interferes with terminal cell differentiation, but not cell 
      specification. We therefore propose that Luna is a novel transcriptional 
      determinant of Drosophila development.
FAU - De Graeve, Fabienne
AU  - De Graeve F
AD  - INSERM UMR 384, Faculte de Medecine, 28 Place Henri Dunant BP38, Cedex 63001, 
      Clermont-Ferrand, France.
FAU - Smaldone, Silvia
AU  - Smaldone S
FAU - Laub, Friedrich
AU  - Laub F
FAU - Mlodzik, Marek
AU  - Mlodzik M
FAU - Bhat, Manzoor
AU  - Bhat M
FAU - Ramirez, Francesco
AU  - Ramirez F
LA  - eng
SI  - GENBANK/AF461497
GR  - AR-38648/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (KLF6 protein, human)
RN  - 0 (KLF7 protein, human)
RN  - 0 (Kruppel-Like Factor 6)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (luna protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Genetically Modified
MH  - DNA, Complementary/chemistry/genetics
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Drosophila Proteins/*genetics/metabolism
MH  - Drosophila melanogaster/*genetics/growth & development
MH  - Evolution, Molecular
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - In Situ Hybridization
MH  - Kruppel-Like Factor 6
MH  - Kruppel-Like Transcription Factors
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phylogeny
MH  - *Proto-Oncogene Proteins
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Trans-Activators/*genetics/metabolism
MH  - Transcription Factors/*genetics/metabolism
EDAT- 2003/10/07 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/07 05:00
PHST- 2003/10/07 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/07 05:00 [entrez]
AID - S0378111903007200 [pii]
AID - 10.1016/s0378-1119(03)00720-0 [doi]
PST - ppublish
SO  - Gene. 2003 Sep 18;314:55-62. doi: 10.1016/s0378-1119(03)00720-0.