PMID- 14527733
OWN - NLM
STAT- MEDLINE
DCOM- 20040525
LR  - 20221207
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 33
IP  - 1
DP  - 2003 Oct
TI  - Association of HLA class I alleles with psoriasis vulgaris in southeastern 
      Chinese Hans.
PG  - 1-6
AB  - BACKGROUND: Predisposing genetic factors in psoriasis include associations with 
      human leukocyte antigen (HLA). Accumulative evidence has shown that certain HLA 
      at class I locus, especially HLA-Cw6, are associated closely with psoriasis. 
      OBJECTIVE: To evaluate the association of HLA class I alleles with susceptibility 
      to psoriasis in the southeastern Chinese Han population. METHODS: We performed 
      genotype for HLA-A, -B and -C loci in 166 patients with psoriasis vulgaris by 
      means of polymerase chain reaction with sequence-specific primers technique. The 
      distribution of HLA allelic frequencies was further analyzed according to age of 
      onset, i.e. under 35-y and beyond 35-y groups. These data were compared with the 
      healthy controls of 204 unrelated Hans. RESULTS: The frequencies of HLA-A*26 
      (24.7% vs. 13.1%, OR=2.36, Pc<0.01), -B*13 (27.2% vs. 14.8%, OR=2.34, Pc<0.01), 
      -B*27 (12.2% vs. 4.0%, OR=3.49, Pc<0.01) and -Cw*0602 (17.9% vs. 5.3%, OR=4.20, 
      Pc<0.001) were significantly increased in psoriasis patients, whereas HLA-Cw*0304 
      frequency (4.9% vs. 13.4%, OR=0.32, Pc<0.01) was highly decreased, when compared 
      to the controls. HLA-A*26-B*27-Cw*0602 was identified as a high-risk haplotype of 
      HLA class I in developing psoriasis in the test. HLA-Cw*0602 was found to be 
      strongly associated with the early-onset psoriasis (age of onset <35 y). 
      CONCLUSION: This study demonstrated the positive associations of HLA class I 
      markers with psoriasis vulgaris, of which HLA-Cw*0602 was the strongest 
      susceptibility determinant for development of early-onset psoriasis, in the 
      southeastern Chinese Han population.
FAU - Zhang, Xue-Jun
AU  - Zhang XJ
AD  - Institute of Dermatology, Anhui Medical University, No. 69 Meishan Road, Hefei, 
      Anhui 230032, PR China. ayzxj@mail.hf.ah.cn
FAU - Zhang, An-Ping
AU  - Zhang AP
FAU - Yang, Sen
AU  - Yang S
FAU - Gao, Min
AU  - Gao M
FAU - Wei, Sheng-Cai
AU  - Wei SC
FAU - He, Ping-Ping
AU  - He PP
FAU - Wang, Hong-Yan
AU  - Wang HY
FAU - Song, Ying-Xue
AU  - Song YX
FAU - Cui, Yong
AU  - Cui Y
FAU - Chen, Jian-Jun
AU  - Chen JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - *Alleles
MH  - Asian People/*genetics
MH  - Chromosome Mapping
MH  - Female
MH  - Gene Frequency
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Psoriasis/epidemiology/*genetics/*immunology
EDAT- 2003/10/07 05:00
MHDA- 2004/05/27 05:00
CRDT- 2003/10/07 05:00
PHST- 2003/10/07 05:00 [pubmed]
PHST- 2004/05/27 05:00 [medline]
PHST- 2003/10/07 05:00 [entrez]
AID - S0923181103001579 [pii]
AID - 10.1016/s0923-1811(03)00157-9 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2003 Oct;33(1):1-6. doi: 10.1016/s0923-1811(03)00157-9.