PMID- 14528089
OWN - NLM
STAT- MEDLINE
DCOM- 20040219
LR  - 20041117
IS  - 1537-453X (Electronic)
IS  - 0277-3732 (Linking)
VI  - 26
IP  - 5
DP  - 2003 Oct
TI  - Patient-reported toxicity correlated to dose-volume histograms of the rectum in 
      radiotherapy of the prostate.
PG  - e144-9
AB  - We studied 73 patients treated with 3-dimensional conformal radiotherapy for 
      prostate cancer to determine whether there is a correlation between dose per 
      volume to either the whole rectum, rectal wall, rectal surface, or anal canal and 
      the development of late rectal complications measured with prostate-specific 
      quality-of-life (QOL) questionnaires. Given doses were 66.6 to 72 Gy. The 
      prostate cancer modules used were the UCLA-Prostate Cancer Index module 
      (UCLA-PCI) (5 questions), the Functional Assessment of Cancer Therapy-Prostate 
      module (FACT-P) (1 question), and the European Organization for Research and 
      Treatment of Cancer prostate cancer module (EORTC QLQ-PR25) (4 questions). A 
      Spearman correlation analysis between the total toxicity score and the 
      dose-volume histograms (DVHs) was performed. All statistical tests were 2-sided. 
      Sixty-five (89%) patients returned the questionnaire, and 18 (28%) underwent 
      endoscopy for rectal bleeding. We found that only patients who had had an 
      endoscopy showed a correlation between rectal toxicity and dose per volume, as 
      compared with the other patients who showed none. Correlation between rectal 
      toxicity and dose per volume for all 4 structures was stronger for higher doses. 
      For 70 Gy, all contours, except the anal canal, showed a significant dose-volume 
      correlation. Our results indicate that only in cases of pronounced rectal 
      toxicity is there a dose-volume correlation, especially for doses of 70 Gy or 
      more. DVHs of the whole rectum, wall, or surface, but not the anal canal, are all 
      equivalent in predicting late rectal toxicity.
FAU - Taussky, Daniel
AU  - Taussky D
AD  - Department of Radiation Oncology and Nuclear Medicine, Triemli Hospital, Zurich, 
      Switzerland. dantaussky@hotmail.com
FAU - Schneider, Uwe
AU  - Schneider U
FAU - Rousson, Valentin
AU  - Rousson V
FAU - Pescia, Raoul
AU  - Pescia R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Clin Oncol
JT  - American journal of clinical oncology
JID - 8207754
SB  - IM
MH  - Aged
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostatic Neoplasms/*radiotherapy
MH  - Quality of Life
MH  - Radiotherapy, Conformal
MH  - Rectum/*radiation effects
EDAT- 2003/10/07 05:00
MHDA- 2004/02/20 05:00
CRDT- 2003/10/07 05:00
PHST- 2003/10/07 05:00 [pubmed]
PHST- 2004/02/20 05:00 [medline]
PHST- 2003/10/07 05:00 [entrez]
AID - 10.1097/01.coc.0000091355.26165.81 [doi]
PST - ppublish
SO  - Am J Clin Oncol. 2003 Oct;26(5):e144-9. doi: 10.1097/01.coc.0000091355.26165.81.