PMID- 14529794
OWN - NLM
STAT- MEDLINE
DCOM- 20031121
LR  - 20191210
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 57
IP  - 3
DP  - 2003 Nov 1
TI  - Validation of active breathing control in patients with non-small-cell lung 
      cancer to be treated with CHARTWEL.
PG  - 864-74
AB  - PURPOSE: Active breathing control (ABC) was validated using patients with 
      non-small-cell lung cancer (NSCLC) to be treated with continuous 
      hyperfractionated accelerated radiotherapy weekend-less (CHARTWEL). Effects of 
      breath hold (BH) on accuracy and normal tissue doses were evaluated. METHODS AND 
      MATERIALS: Eleven patients were studied. Immediately after a free breathing (FB) 
      planning scan, two ABC scans (ABC 1 and 2) were performed to assess intrafraction 
      variation. A third ABC scan (ABC 3) was performed some weeks later to assess 
      interfraction variation. Assisted BH was set at 75% of vital capacity and 
      reproducibility assessed using computed tomography (CT) lung volumes. Planning 
      target volumes (PTVs), doses to lung and spinal cord for FB and ABC 1 scans were 
      compared. RESULTS: Results were available for 10 patients. Disease and elective 
      nodal regions were easier to define on ABC scans making PTVs smaller. ABC lung 
      volumes showed no significant variation over several weeks, percentage volume of 
      whole lung receiving > or =20 Gy (V(20)) was reduced in all (median 6.4%, p = 
      0.005), and spinal cord dose in 80% (median 1.03 Gy, p = 0.02), of the plans. 
      CONCLUSION: ABC allowed reproducible BH, and enabled better delineation of tumor 
      and normal structures, as well as reduction in PTV, V(20), and spinal cord dose.
FAU - Wilson, Elena M
AU  - Wilson EM
AD  - Department of Clinical OncologyMount Vernon Cancer Centre, Northwood, Middlesex, 
      UK. EMW@tinyworld.co.uk
FAU - Williams, F Joy
AU  - Williams FJ
FAU - Lyn, B Ethan
AU  - Lyn BE
FAU - Wong, John W
AU  - Wong JW
FAU - Aird, Edwin G A
AU  - Aird EG
LA  - eng
GR  - R01 CA 76182/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Validation Study
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/*radiotherapy
MH  - Dose Fractionation, Radiation
MH  - Equipment Design
MH  - Female
MH  - Humans
MH  - Inhalation
MH  - Lung Neoplasms/diagnostic imaging/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - *Respiration
MH  - Tomography, X-Ray Computed
MH  - Vital Capacity
EDAT- 2003/10/08 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/08 05:00
PHST- 2003/10/08 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/08 05:00 [entrez]
AID - S0360301603007120 [pii]
AID - 10.1016/s0360-3016(03)00712-0 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):864-74. doi: 
      10.1016/s0360-3016(03)00712-0.