PMID- 14530719 OWN - NLM STAT- MEDLINE DCOM- 20031107 LR - 20221207 IS - 0003-4932 (Print) IS - 1528-1140 (Electronic) IS - 0003-4932 (Linking) VI - 238 IP - 4 DP - 2003 Oct TI - Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. PG - 467-84; discussion 84-5 AB - OBJECTIVE: To evaluate pre- and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM). SUMMARY BACKGROUND DATA: The surgical treatment of morbid obesity leads to dramatic improvement in the comorbidity status of most patients with T2DM. However, little is known concerning what preoperative clinical factors are associated with postoperative long-term improvement in diabetes in the morbidly obese patient with diabetes. METHODS We evaluated pre- and postoperative data, including demographics, duration of diabetes, metabolic parameters, and clinical outcomes, in all patients with impaired fasting glucose (IFG) and type T2DM undergoing LRYGBP from July 1997 to May 2002. RESULTS: During this 5-year period, 1160 patients underwent LRYGBP and 240 (21%) had IFG or T2DM. Follow up was possible in 191 of 240 patients (80%). There were 144 females (75%) with a mean preoperative age of 48 years (range, 26-67 years). After surgery, weight and body mass index decreased from 308 lbs and 50.1 kg/m2 to 211 lbs and 34 kg/m2 for a mean weight loss of 97 lbs and mean excess weight loss of 60%. Fasting plasma glucose and glycosylated hemoglobin concentrations returned to normal levels (83%) or markedly improved (17%) in all patients. A significant reduction in use of oral antidiabetic agents (80%) and insulin (79%) followed surgical treatment. Patients with the shortest duration (<5 years), the mildest form of T2DM (diet controlled), and the greatest weight loss after surgery were most likely to achieve complete resolution of T2DM. CONCLUSION: LRYGBP resulted in significant weight loss (60% percent of excess body weight loss) and resolution (83%) of T2DM. Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery, suggesting that early surgical intervention is warranted to increase the likelihood of rendering patients euglycemic. FAU - Schauer, Philip R AU - Schauer PR AD - Departments of Surgery, University of Pittsburg, Pittsburgh, PA, USA. schauerpr@msx.upmx.edu FAU - Burguera, Bartolome AU - Burguera B FAU - Ikramuddin, Sayeed AU - Ikramuddin S FAU - Cottam, Dan AU - Cottam D FAU - Gourash, William AU - Gourash W FAU - Hamad, Giselle AU - Hamad G FAU - Eid, George M AU - Eid GM FAU - Mattar, Samer AU - Mattar S FAU - Ramanathan, Ramesh AU - Ramanathan R FAU - Barinas-Mitchel, Emma AU - Barinas-Mitchel E FAU - Rao, R Harsha AU - Rao RH FAU - Kuller, Lewis AU - Kuller L FAU - Kelley, David AU - Kelley D LA - eng PT - Journal Article PL - United States TA - Ann Surg JT - Annals of surgery JID - 0372354 RN - 0 (Glycated Hemoglobin A) RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) SB - IM MH - Adult MH - Anastomosis, Roux-en-Y MH - Body Mass Index MH - Comorbidity MH - Diabetes Mellitus/blood/epidemiology/*physiopathology/*surgery MH - Diabetes Mellitus, Type 2/blood/drug therapy/epidemiology/*physiopathology MH - Female MH - *Gastric Bypass/methods MH - Glycated Hemoglobin/analysis MH - Humans MH - Hypoglycemic Agents/therapeutic use MH - Insulin/therapeutic use MH - Laparoscopy MH - Male MH - Middle Aged MH - *Obesity MH - Postoperative Period MH - Treatment Outcome MH - Weight Loss PMC - PMC1360104 EDAT- 2003/10/08 05:00 MHDA- 2003/11/08 05:00 PMCR- 2004/04/01 CRDT- 2003/10/08 05:00 PHST- 2003/10/08 05:00 [pubmed] PHST- 2003/11/08 05:00 [medline] PHST- 2003/10/08 05:00 [entrez] PHST- 2004/04/01 00:00 [pmc-release] AID - 0000658-200310000-00003 [pii] AID - 10.1097/01.sla.0000089851.41115.1b [doi] PST - ppublish SO - Ann Surg. 2003 Oct;238(4):467-84; discussion 84-5. doi: 10.1097/01.sla.0000089851.41115.1b.