PMID- 14550823
OWN - NLM
STAT- MEDLINE
DCOM- 20040211
LR  - 20190922
IS  - 1053-2498 (Print)
IS  - 1053-2498 (Linking)
VI  - 22
IP  - 10
DP  - 2003 Oct
TI  - Benefits of cardiac resynchronization therapy in outpatients with indicators for 
      heart transplantation.
PG  - 1134-40
AB  - BACKGROUND: Despite several new advances in the treatment of end-stage congestive 
      heart failure (CHF) the number of patients moving onto the heart transplant list 
      continues to rise. Recently, cardiac resynchronization therapy (CRT) has become a 
      Food and Drug Administration (FDA)-approved therapy for advanced CHF. Currently, 
      there are no available data on CRT in cardiac transplant candidates. METHODS: To 
      determine the effects of CRT on potential transplant candidates we 
      retrospectively reviewed patients (n = 34) enrolled in resynchronization trials 
      at our center who met accepted criteria for transplantation. Ventricular 
      function, oxygen uptake and New York Heart Association (NYHA) class were compared 
      at baseline and after 6 months of active therapy for each patient. RESULTS: CRT 
      reduced QRS duration from 178 +/- 29 to 143 +/- 17 msec (p < 0.0001) and NYHA 
      class from 3.1 +/- 0.3 to 1.8 +/- 0.7 (p < 0.0001). Ejection fraction (EF) 
      increased from 18.4 +/- 5.1 to 25.1 +/- 8.4% (p < 0.0001) and maximum VO(2) 
      increased from 11.9 +/- 1.8 to 15.3 +/- 3 ml/kg/min (p < 0.0001). Only 2 of the 
      initial 34 patients still met the criteria for transplantation at 6 months. 
      CONCLUSIONS: CRT improves ventricular function, oxygen uptake and NYHA class in 
      ambulatory patients who have a QRS of >130 msec and might be considered 
      candidates for cardiac transplantation. Transplantation can be prevented or 
      deferred in the majority of patients. Outpatients with chronic CHF and a widened 
      QRS should be evaluated for CRT before being listed for cardiac transplantation.
FAU - Greenberg, Jeffrey M
AU  - Greenberg JM
AD  - Center for Heart Failure Therapy, Emory University School of Medicine, 1364 
      Clifton Road NE, Suite 508, Atlanta, GA 30322, USA.
FAU - Leon, Angel R
AU  - Leon AR
FAU - Book, Wendy M
AU  - Book WM
FAU - Hott, Brenda J
AU  - Hott BJ
FAU - DeLurgio, David B
AU  - DeLurgio DB
FAU - Langberg, Jonathan J
AU  - Langberg JJ
FAU - Smith, Andrew L
AU  - Smith AL
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Cardiac Pacing, Artificial/methods
MH  - Electrocardiography
MH  - Female
MH  - Heart Failure/*therapy
MH  - *Heart Transplantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outpatients
MH  - *Pacemaker, Artificial
MH  - Retrospective Studies
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/therapy
EDAT- 2003/10/11 05:00
MHDA- 2004/02/12 05:00
CRDT- 2003/10/11 05:00
PHST- 2003/10/11 05:00 [pubmed]
PHST- 2004/02/12 05:00 [medline]
PHST- 2003/10/11 05:00 [entrez]
AID - S1053249802011907 [pii]
AID - 10.1016/s1053-2498(02)01190-7 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2003 Oct;22(10):1134-40. doi: 
      10.1016/s1053-2498(02)01190-7.