PMID- 14550881
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20191108
IS  - 1568-9972 (Print)
IS  - 1568-9972 (Linking)
VI  - 2
IP  - 6
DP  - 2003 Oct
TI  - HLA class II alleles and genetic predisposition to the antiphospholipid syndrome.
PG  - 387-94
AB  - The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the 
      presence of antiphospholipid antibodies (aPL). Its etiology is linked to genetic 
      predisposition, which is accounted for, at least in part, by genes of major 
      histocompatibility complex (HLA system). The association of APS with human 
      leukocyte antigen (HLA) alleles is a consequence of the association of aPL with 
      HLA alleles. Some HLA alleles carry the risk to produce aPL, and this is 
      independent of the clinical context. In fact, we find the same associations 
      between HLA and aPL in primary APS and in APS secondary to systemic lupus 
      erythematosus (SLE). The association of HLA-DR4, -DR7, -DRw53 and -DQB1*0302 with 
      aCL that has been demonstrated in primary APS can also be found in SLE, a disease 
      with a completely different pattern of HLA allele association (DR2, DR3, DRw52). 
      In addition, the various aPL (anticardiolipin antibodies, lupus anticoagulant, 
      anti-beta2GPI antibodies, antiphosphatidylserine/prothrombin antibodies) show 
      similar HLA association, again independent of the clinical context (primary APS 
      or SLE), and across various ethnic groups.
FAU - Domenico Sebastiani, Gian
AU  - Domenico Sebastiani G
AD  - Unita Operativa Complessa di Reumatologia, Azienda Ospedaliera San 
      Camillo--Forlanini, Circonvallazione Gianicolense n. 87, 00152 Rome, Italy. 
      gsebastiani@scamilloforlanini.rm.it
FAU - Minisola, Giovanni
AU  - Minisola G
FAU - Galeazzi, Mauro
AU  - Galeazzi M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - *Alleles
MH  - Antiphospholipid Syndrome/*genetics
MH  - *Genes, MHC Class II
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
RF  - 35
EDAT- 2003/10/11 05:00
MHDA- 2004/01/07 05:00
CRDT- 2003/10/11 05:00
PHST- 2003/10/11 05:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/10/11 05:00 [entrez]
AID - S1568997203000685 [pii]
AID - 10.1016/s1568-9972(03)00068-5 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2003 Oct;2(6):387-94. doi: 10.1016/s1568-9972(03)00068-5.