PMID- 14550978
OWN - NLM
STAT- MEDLINE
DCOM- 20031216
LR  - 20190901
IS  - 0929-693X (Print)
IS  - 0929-693X (Linking)
VI  - 10
IP  - 10
DP  - 2003 Oct
TI  - [Juvenile myelomonocytic leukaemia, xanthoma, and neurofibromatosis type 1].
PG  - 891-4
AB  - The triple association of leukemia, xanthogranulomas, and type 1 
      neurofibromatosis was first described in 1958. Most leukemias were juvenile 
      myelomonocytic leukemias (JMML), usually called juvenile chronic myelogenous 
      leukemia. We describe a 22-month-old female child with neurofibromatosis 1, 
      xanthomagranulomas, and a JMML. Her mother and her brother also had cutaneous 
      cafe-au-lait spots. Our patient was treated with mercaptopurine and improved. 
      However, 9 months later she experienced a blastic transformation. The presence of 
      xanthomagranulomas and NF1 in a young child should alert to a possible 
      development of JMML, especially in patients with a family history of NF1.
FAU - Benessahraoui, M
AU  - Benessahraoui M
AD  - Service de dermatologie 1, CHU de Besancon, 2, place Saint-Jacques, 25030 
      Besancon, France.
FAU - Aubin, F
AU  - Aubin F
FAU - Paratte, F
AU  - Paratte F
FAU - Plouvier, E
AU  - Plouvier E
FAU - Humbert, P
AU  - Humbert P
LA  - fre
PT  - Journal Article
TT  - Leucemie myelomonocytaire juvenile, xanthomes et neurofibromatose de type 1.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
RN  - 0 (Antimetabolites, Antineoplastic)
RN  - E7WED276I5 (Mercaptopurine)
SB  - IM
MH  - Antimetabolites, Antineoplastic/therapeutic use
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Infant
MH  - Leukemia, Myelomonocytic, Chronic/*complications/drug therapy/pathology
MH  - Mercaptopurine/therapeutic use
MH  - Neurofibromatosis 1/*complications/pathology
MH  - Xanthogranuloma, Juvenile/*complications/pathology
EDAT- 2003/10/11 05:00
MHDA- 2003/12/17 05:00
CRDT- 2003/10/11 05:00
PHST- 2003/10/11 05:00 [pubmed]
PHST- 2003/12/17 05:00 [medline]
PHST- 2003/10/11 05:00 [entrez]
AID - S0929693X03004561 [pii]
AID - 10.1016/s0929-693x(03)00456-1 [doi]
PST - ppublish
SO  - Arch Pediatr. 2003 Oct;10(10):891-4. doi: 10.1016/s0929-693x(03)00456-1.