PMID- 14553944
OWN - NLM
STAT- MEDLINE
DCOM- 20031103
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 146
IP  - 2
DP  - 2003 Oct 15
TI  - DNA gains at 8q23.2: a potential early marker in head and neck carcinomas.
PG  - 110-5
AB  - Gains or amplifications involving chromosome arm 8q are one of the most recurrent 
      chromosomal alterations in head and neck tumors. To characterize previously 
      reported gains, we performed fluorescence in situ hybridization (FISH) using the 
      sequences BAC RP1179E1 and 8-centromere PMJ 128 as probes. Gains and/or 
      amplifications were detected in all 19 cases evaluated by FISH. The FISH 
      analysis, but not G-banding, revealed homogeneously staining region in three 
      cases. We conclude that gains of one or more genes on chromosome arm 8q may be 
      important for the early stages of head and neck carcinomas.
FAU - da Silva Veiga, Luciana Caricati
AU  - da Silva Veiga LC
AD  - Departamento de Genetica, Instituto de Biociencias, Universidade Estadual 
      Paulista, Botucatu, SP, Brazil.
FAU - Bergamo, Nadia Aparecida
AU  - Bergamo NA
FAU - dos Reis, Patricia Pintor
AU  - dos Reis PP
FAU - Kowalski, Luis Paulo
AU  - Kowalski LP
FAU - Rogatto, Silvia Regina
AU  - Rogatto SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor
MH  - Carcinoma, Squamous Cell/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 8
MH  - DNA, Neoplasm/*analysis
MH  - Female
MH  - Head and Neck Neoplasms/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Male
MH  - Middle Aged
EDAT- 2003/10/14 05:00
MHDA- 2003/11/05 05:00
CRDT- 2003/10/14 05:00
PHST- 2003/10/14 05:00 [pubmed]
PHST- 2003/11/05 05:00 [medline]
PHST- 2003/10/14 05:00 [entrez]
AID - S0165460803001328 [pii]
AID - 10.1016/s0165-4608(03)00132-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Oct 15;146(2):110-5. doi: 
      10.1016/s0165-4608(03)00132-8.