PMID- 14556105
OWN - NLM
STAT- MEDLINE
DCOM- 20031202
LR  - 20151119
IS  - 1438-9029 (Print)
IS  - 1438-9010 (Linking)
VI  - 175
IP  - 10
DP  - 2003 Oct
TI  - [Enhanced MR-angiography (CE-MRA) of the supraaortic arteries: dose reduction 
      with a contrast agent of high relaxivity (Gd-BOPTA)].
PG  - 1363-7
AB  - PURPOSE: Reducing the amount of contrast medium in contrast-enhanced 
      MR-angiography (CE-MRA) of the cervical vessels could lead to considerable cost 
      reduction. This study investigates whether the amount of contrast medium 
      possessing high relaxivity can be reduced without loss of diagnostic information. 
      MATERIALS AND METHODS: In a prospective study the supraaortic vessels of 40 
      patients were examined on a 1.5 T MR-system using 10 or 20 ml Gd-BOPTA 
      (MultiHance). The examinations were evaluated by measurement of the signal 
      increase in the common carotid arteries in 38 patients. Furthermore, CE-MRA was 
      rated by two independent observers, who were blinded to the amount of contrast 
      medium and degree of stenosis. Rating criteria were quality of arterial contrast 
      and image impression. RESULTS: Signal increase in the carotid artery was 
      identical for 10 and 20 ml Gd-BOPTA in 12 patients with optimal bolus timing (10 
      ml: 454 +/- 58; 20 ml: 458 +/- 63). Signal intensities were significantly lower 
      for 10 ml when bolus timing was suboptimal (281 +/- 80 vs 353 +/- 65; p < 0.02). 
      The quality of the CE-MRA using 10 and 20 ml Gd- BOPTA was rated as identical by 
      the observers, and the amount of contrast medium used could not be deduced from 
      the images. CONCLUSION: Image quality and signal values of the carotid arteries 
      did not differ in CE-MRA performed with either 10 ml or 20 ml Gd-BOPTA 
      (MultiHance) as long as the examination is adequate. Thus, cost reduction can be 
      achieved with a reduced standard dose of 10 ml Gd-BOPTA without loss of 
      diagnostic information.
FAU - Friese, S
AU  - Friese S
AD  - Abteilung fur Neuroradiologie, Radiologische Klinik Eberhard-Karls-Universitat 
      Tubingen. sigrid.friese@med.uni-tuebingen.de
FAU - Klose, U
AU  - Klose U
FAU - Kastrup, A
AU  - Kastrup A
FAU - Krapf, H
AU  - Krapf H
FAU - Kuker, W
AU  - Kuker W
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Kontrastmittelverstarkte MR-Angiographie (CE-MRA) der supraaortalen Arterien: 
      Dosisreduktion bei einem Kontrastmittel hoher Relaxivitat (Gd-BOPTA).
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotid Artery, Internal/*pathology
MH  - Carotid Stenosis/*diagnosis
MH  - Contrast Media/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Meglumine/*analogs & derivatives
MH  - Middle Aged
MH  - *Organometallic Compounds
MH  - Sensitivity and Specificity
EDAT- 2003/10/14 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/14 05:00
PHST- 2003/10/14 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/14 05:00 [entrez]
AID - 10.1055/s-2003-42883 [doi]
PST - ppublish
SO  - Rofo. 2003 Oct;175(10):1363-7. doi: 10.1055/s-2003-42883.