PMID- 14556721
OWN - NLM
STAT- MEDLINE
DCOM- 20040223
LR  - 20220414
IS  - 0305-4179 (Print)
IS  - 0305-4179 (Linking)
VI  - 29
IP  - 7
DP  - 2003 Nov
TI  - Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the 
      skin after burn injury in aged mice.
PG  - 641-7
AB  - Clinical observations and laboratory studies have shown a delay in dermal wound 
      healing in aged subjects. Since macrophages play a key role in wound healing, we 
      investigated age related differences in MCP-1 production and monocyte recruitment 
      to the wound following burn injury using a murine model. The present study shows 
      that there is an increase in MCP-1 levels in the burned-normal skin interface at 
      1-day post burn in both young and aged burned mice compared to sham injured mice. 
      However, the levels of MCP-1 in aged burned mice (133.16+/-36.55pg/mg protein) 
      were approximately half the levels of young burned mice (286.15+/-45.36pg/mg 
      protein, P<0.05). Additionally, at 4 days post burn, MCP-1 levels in aged mice 
      (290.73+/-101.98) reached the same levels as in young mice (243.97+/-36.71). 
      There was no difference in macrophage accumulation into the wound between young 
      and aged at either time point. These data demonstrate that the difference in 
      dermal MCP-1 levels between the young and aged is not associated with a 
      difference in macrophage infiltration to the wound following burn injury, 
      suggesting that the lower MCP-1 content in the aged is possibly affecting other 
      phases of wound healing in the aged.
FAU - Shallo, Hilda
AU  - Shallo H
AD  - Department of Cell Biology, 2160 South First Avenue, Stritch School of Medicine, 
      Loyola University Chicago, 60513, Maywood, IL, USA.
FAU - Plackett, Timothy P
AU  - Plackett TP
FAU - Heinrich, Scott A
AU  - Heinrich SA
FAU - Kovacs, Elizabeth J
AU  - Kovacs EJ
LA  - eng
GR  - AG18859/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aging/*metabolism/physiology
MH  - Animals
MH  - Burns/*metabolism/physiopathology
MH  - Chemokine CCL2/*metabolism
MH  - Female
MH  - Macrophages/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Skin/*metabolism
MH  - Wound Healing/physiology
EDAT- 2003/10/15 05:00
MHDA- 2004/02/24 05:00
CRDT- 2003/10/15 05:00
PHST- 2003/10/15 05:00 [pubmed]
PHST- 2004/02/24 05:00 [medline]
PHST- 2003/10/15 05:00 [entrez]
AID - S0305417903000706 [pii]
AID - 10.1016/s0305-4179(03)00070-6 [doi]
PST - ppublish
SO  - Burns. 2003 Nov;29(7):641-7. doi: 10.1016/s0305-4179(03)00070-6.