PMID- 14557841
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20200413
IS  - 0021-7557 (Print)
IS  - 0021-7557 (Linking)
VI  - 79
IP  - 5
DP  - 2003 Sep-Oct
TI  - [Clinical and epidemiological analysis of bone marrow transplantation in a 
      pediatric oncology unit].
PG  - 413-22
AB  - OBJECTIVE: To describe the demographics and the most important acute clinical 
      complications in patients undergoing bone marrow transplantation in the Pediatric 
      Oncology Unit at Hospital de Clinicas de Porto Alegre, Brazil. MATERIAL AND 
      METHODS: A retrospective analysis was performed including 41 patients treated 
      between August 1997 and June 2002. Twenty patients received allogeneic 
      transplants (AG) and 21 received autologous transplants (AT). RESULTS: The mean 
      age of AG patients was 8.9 +/- 5.4 years. Twelve patients were male. Stem cell 
      sources were: bone marrow in 12 patients; peripheral blood in five; and unrelated 
      cord blood in three. The diseases were acute lymphoid leukemia in seven patients; 
      acute myeloid leukemia in four; chronic myeloid leukemia in two; myelodysplastic 
      syndrome in two; Burkitt's lymphoma in one; severe combined immunodeficiency in 
      one; Chediaki-Higashi syndrome in one; Fanconi anemia in one; and aplastic anemia 
      in one. One patient developed grade II acute graft-versus-host-disease (GVHD), 
      and three patients had grade IV GVHD. Three patients developed chronic GVHD. In 
      all of them, the cell source was peripheral blood. Survival in this group was 
      70.0 +/- 10.3%. The main cause of death was GVHD in three patients and sepsis in 
      another three. All deaths occurred before day 100. One of the patients who 
      received unrelated cord blood is alive 3.5 years after the transplantation. In AG 
      patients, mean age was 8.7 +/- 4.3 years. Eleven patients were male. The stem 
      cell sources were: peripheral blood in 16; bone marrow in three; and peripheral 
      blood + bone marrow in two. The diseases were: Wilms' tumor in five patients; 
      Ewing's sarcoma family tumors in four; neuroblastoma in three; Hodgkin's disease 
      in three; non-Hodgkin's lymphoma in one; rhabdomyosarcoma in two; neuroectodermic 
      tumor of the central nervous system in two; acute myeloid leukemia in one. 
      Survival in this group was 59.4 +/- 11.7%. Five patients died due to tumor 
      relapse, two patients due to sepsis and one patient died in remission 20 months 
      after bone marrow transplantation due to infection. In the whole group, the most 
      common toxicities were vomiting, mucositis, diarrhea and abdominal pain. 
      Infections were recorded in 58.5% of the patients. In 46.9%, at least one 
      pathogen was isolated in the blood culture. The time required for neutrophil and 
      platelet engraftment was correlated to the number of hematopoietic stem cell 
      infused. CONCLUSION: The overall survival in our patients is similar to that 
      reported in the literature. We did not find differences between AT and AG 
      patients regarding acute toxicities and infections.
FAU - de Castro, Claudio Galvao Jr
AU  - de Castro CG Jr
AD  - Programa de Pos-graduacao em Ciencias Medicas, Faculdade de Medicina, 
      Universidade Federal do Rio Grande do Sul. cgcastro@hcpa.ufrgs.br
FAU - Gregianin, Lauro Jose
AU  - Gregianin LJ
FAU - Brunetto, Algemir Lunardi
AU  - Brunetto AL
LA  - por
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Analise clinica e epidemiologica do transplante de medula ossea em um servico de 
      oncologia pediatrica.
PL  - Brazil
TA  - J Pediatr (Rio J)
JT  - Jornal de pediatria
JID - 2985188R
SB  - IM
CIN - J Pediatr (Rio J). 2003 Sep-Oct;79(5):383-4. PMID: 14557836
MH  - Adolescent
MH  - Adult
MH  - Bone Marrow Transplantation/*adverse effects/mortality/statistics & numerical 
      data
MH  - Brazil/epidemiology
MH  - Child
MH  - Cord Blood Stem Cell Transplantation
MH  - Cross Infection/epidemiology
MH  - Disease-Free Survival
MH  - Female
MH  - Graft vs Host Disease/epidemiology
MH  - Host vs Graft Reaction
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Neoplasms/*surgery
MH  - Oncology Service, Hospital
MH  - Retrospective Studies
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
EDAT- 2003/10/15 05:00
MHDA- 2004/03/05 05:00
CRDT- 2003/10/15 05:00
PHST- 2003/10/15 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2003/10/15 05:00 [entrez]
PST - ppublish
SO  - J Pediatr (Rio J). 2003 Sep-Oct;79(5):413-22.