PMID- 14559032
OWN - NLM
STAT- MEDLINE
DCOM- 20040621
LR  - 20190922
IS  - 0143-4004 (Print)
IS  - 0143-4004 (Linking)
VI  - 24 Suppl B
DP  - 2003 Oct
TI  - Genetic analysis of sperm and implications of severe male infertility--a review.
PG  - S62-5
AB  - The use of fluorescence in situ hybridization (FISH) on decondensed sperm heads 
      has allowed to analyse the chromosome constitution of spermatozoa in different 
      populations. In controls, the mean incidence of disomy (including all 
      chromosomes) is about 6.7 per cent; diploidy increases with age, and some 
      individuals may show a special tendency to nondisjunction. Carriers of numerical 
      sex chromosome anomalies show a low incidence of sex chromosome disomies 
      (2.54-7.69 per cent), and the need to screen ICSI candidates for these conditions 
      has to be reconsidered. Carriers of inversions produce from 0 to 54.3 per cent 
      abnormal sperm. Carriers of Robertsonian translocations produce from 3.4 to 36.0 
      per cent abnormal sperm, and carriers of reciprocal translocations produce from 
      47.5 to 81.0 per cent abnormal spermatozoa. However, carriers of translocations 
      usually produce more abnormal embryos than expected from these figures. This may 
      be partly related to interchromosomal effects induced by some structural 
      reorganizations. Males with oligoasthenozoospermia, low motility and/or high FSH 
      concentrations show frequent synaptic anomalies, resulting in the production of 
      aneuploid and diploid sperm. Testicular sperm show extremely high rates of 
      chromosomal abnormalities. The risk of recurrent abortion is increased by the 
      presence of chromosome abnormalities in sperm.
FAU - Egozcue, J
AU  - Egozcue J
AD  - Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de 
      Barcelona, 08193 Bellaterra, Spain. josep.egozcue@uab.es
FAU - Blanco, J
AU  - Blanco J
FAU - Anton, E
AU  - Anton E
FAU - Egozcue, S
AU  - Egozcue S
FAU - Sarrate, Z
AU  - Sarrate Z
FAU - Vidal, F
AU  - Vidal F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
SB  - IM
MH  - Cell Nucleus
MH  - *Chromosome Aberrations
MH  - *Genetic Predisposition to Disease
MH  - *Genetic Testing
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Spermatozoa/*abnormalities
RF  - 61
EDAT- 2003/10/16 05:00
MHDA- 2004/06/24 05:00
CRDT- 2003/10/16 05:00
PHST- 2003/10/16 05:00 [pubmed]
PHST- 2004/06/24 05:00 [medline]
PHST- 2003/10/16 05:00 [entrez]
AID - S0143400403001863 [pii]
AID - 10.1016/s0143-4004(03)00186-3 [doi]
PST - ppublish
SO  - Placenta. 2003 Oct;24 Suppl B:S62-5. doi: 10.1016/s0143-4004(03)00186-3.