PMID- 14559106
OWN - NLM
STAT- MEDLINE
DCOM- 20040604
LR  - 20191108
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 14
IP  - 10
DP  - 2003 Oct
TI  - Role of nuclear receptors in the regulation of gene expression by dietary fatty 
      acids (review).
PG  - 554-67
AB  - Long chain fatty acids, derived either from endogenous metabolism or by 
      nutritional sources play significant roles in important biological processes of 
      membrane structure, production of biologically active compounds, and 
      participation in cellular signaling processes. Recently, the structure of dietary 
      fatty acids has become an important issue in human health because ingestion of 
      saturated fats (containing triglycerides composed of saturated fatty acids) is 
      considered harmful, while unsaturated fats are viewed as beneficial. It is 
      important to note that the molecular reason for this dichotomy still remains 
      elusive. Since fatty acids are important players in development of pathology of 
      cardiovascular and endocrine system, understanding the key molecular targets of 
      fatty acids, in particular those that discriminate between saturated and 
      unsaturated fats, is much needed. Recently, insights have been gained on several 
      fatty acid-activated nuclear receptors involved in gene expression. In other 
      words, we can now envision long chain fatty acids as regulators of signal 
      transduction processes and gene regulation, which in turn will dictate their 
      roles in health and disease. In this review, we will discuss fatty acid-mediated 
      regulation of nuclear receptors. We will focus on peroxisome 
      proliferators-activated receptors (PPARs), liver X receptors (LXR), retinoid X 
      receptors (RXRs), and Hepatocyte Nuclear Factor alpha (HNF-4alpha), all of which 
      play pivotal roles in dietary fatty acid-mediated effects. Also, the regulation 
      of gene expression by Conjugated Linoleic Acids (CLA), a family of dienoic fatty 
      acids with a variety of beneficial effects, will be discussed.
FAU - Khan, Seher A
AU  - Khan SA
AD  - Department of Veterinary Science and Center for Molecular Toxicology and 
      Carcinogenesis, Penn State University, University Park, PA 16802, USA.
FAU - Vanden Heuvel, John P
AU  - Vanden Heuvel JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
SB  - IM
MH  - Amino Acid Sequence
MH  - Dietary Fats/*pharmacology
MH  - Fatty Acids/*pharmacology
MH  - Gene Expression Regulation/drug effects/*physiology
MH  - Ligands
MH  - Molecular Sequence Data
MH  - Receptors, Cytoplasmic and Nuclear/chemistry/*physiology
MH  - Sequence Homology, Amino Acid
RF  - 142
EDAT- 2003/10/16 05:00
MHDA- 2004/06/05 05:00
CRDT- 2003/10/16 05:00
PHST- 2003/10/16 05:00 [pubmed]
PHST- 2004/06/05 05:00 [medline]
PHST- 2003/10/16 05:00 [entrez]
AID - S0955286303000986 [pii]
AID - 10.1016/s0955-2863(03)00098-6 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2003 Oct;14(10):554-67. doi: 10.1016/s0955-2863(03)00098-6.