PMID- 14560919
OWN - NLM
STAT- MEDLINE
DCOM- 20040629
LR  - 20190917
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 26
IP  - 9
DP  - 2003 Sep
TI  - Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa.
PG  - 719-22
AB  - The anti-oxidant activities of fucosterol isolated from the marine algae Pelvetia 
      siliquosa were investigated. Fucosterol exhibited a significant decrease in serum 
      transaminase activities elevated by hepatic damage induced by CCl4-intoxication 
      in rats. Fucosterol inhibited the sGOT and sGPT activities by 25.57 and 63.16%, 
      respectively. Fucosterol showed the increase in the anti-oxidant enzymes such as 
      hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase 
      (GSH-px) activities by 33.89, 21.56 and 39.24%, respectively, in CCl4-intoxicated 
      rats. These results suggest that fucosterol possess not only the anti-oxidant, 
      but also the hepatoprotective activities in rats.
FAU - Lee, Sanghyun
AU  - Lee S
AD  - Natural Products Research Institute, Seoul National University, Seoul 110-460, 
      Korea.
FAU - Lee, Yeon Sil
AU  - Lee YS
FAU - Jung, Sang Hoon
AU  - Jung SH
FAU - Kang, Sam Sik
AU  - Kang SS
FAU - Shin, Kuk Hyun
AU  - Shin KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Antioxidants)
RN  - 0 (Hexanes)
RN  - 0 (Plant Extracts)
RN  - 0 (Silymarin)
RN  - 504ZAM710C (fucosterol)
RN  - 99WUK5D0Y8 (Stigmasterol)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.6.1.- (Transaminases)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antioxidants/chemistry/*isolation & purification/*pharmacology
MH  - Carbon Tetrachloride/administration & dosage/adverse effects
MH  - Carbon Tetrachloride Poisoning/diagnosis
MH  - Catalase/biosynthesis/pharmacology
MH  - Chemical and Drug Induced Liver Injury/drug therapy/pathology
MH  - Clinical Enzyme Tests
MH  - Drug Administration Schedule
MH  - Eukaryota/*chemistry
MH  - Glutathione Peroxidase/biosynthesis/pharmacology
MH  - Hexanes
MH  - Injections, Intraperitoneal
MH  - Korea
MH  - Liver/drug effects/enzymology
MH  - Male
MH  - Plant Extracts/administration & dosage/isolation & purification/pharmacokinetics
MH  - Premedication
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silymarin/administration & dosage/pharmacokinetics
MH  - Stigmasterol/analogs & derivatives/chemistry/*isolation & 
      purification/*pharmacology
MH  - Superoxide Dismutase/biosynthesis/pharmacology
MH  - Transaminases/antagonists & inhibitors/biosynthesis/drug effects
EDAT- 2003/10/17 05:00
MHDA- 2004/06/30 05:00
CRDT- 2003/10/17 05:00
PHST- 2003/10/17 05:00 [pubmed]
PHST- 2004/06/30 05:00 [medline]
PHST- 2003/10/17 05:00 [entrez]
AID - 10.1007/BF02976680 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2003 Sep;26(9):719-22. doi: 10.1007/BF02976680.