PMID- 1456179
OWN - NLM
STAT- MEDLINE
DCOM- 19930106
LR  - 20190824
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 37
IP  - 1-2
DP  - 1992 Sep
TI  - The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production 
      from eosinophils.
PG  - 39-43
AB  - We investigated the effect of WEB 2086, a selective platelet-activating factor 
      (PAF) receptor antagonist, on PAF-induced eosinophil chemotaxis and LTC4 
      production. WEB 2086 inhibited PAF-induced eosinophil chemotaxis in normals and 
      asthmatics. To further determine if WEB 2086 is a selective PAF receptor 
      antagonist, we examined the effect of WEB 2086 against 
      formyl-methionyl-leucyl-phenylalanine (fMLP)-induced or eosinophil chemotactic 
      factor of anaphylaxis (ECF-A)-induced eosinophil chemotaxis. WEB 2086 did not 
      have a significant inhibition against fMLP or ECF-A-induced eosinophil 
      chemotaxis. These results suggest that WEB 2086 is a selective and potent 
      inhibitor of PAF-induced eosinophil chemotaxis and LTC4 production from 
      eosinophils, due to its antagonism of PAF-receptors.
FAU - Miyagawa, H
AU  - Miyagawa H
AD  - Allergic Disease Center, Creighton University School of Medicine, Omaha, NE 
      68178.
FAU - Nabe, M
AU  - Nabe M
FAU - Hopp, R J
AU  - Hopp RJ
FAU - Okada, C
AU  - Okada C
FAU - Bewtra, A K
AU  - Bewtra AK
FAU - Townley, G
AU  - Townley G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
RN  - 0 (Azepines)
RN  - 0 (Chemotactic Factors, Eosinophil)
RN  - 0 (Platelet Activating Factor)
RN  - 0 (SRS-A)
RN  - 0 (Triazoles)
RN  - 105219-56-5 (WEB 2086)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Adult
MH  - Asthma/immunology
MH  - Azepines/*pharmacology
MH  - Chemotactic Factors, Eosinophil/pharmacology
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - Eosinophils/*drug effects/metabolism
MH  - Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Male
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Platelet Activating Factor/*antagonists & inhibitors/pharmacology
MH  - SRS-A/*biosynthesis
MH  - Triazoles/*pharmacology
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1007/BF01987888 [doi]
PST - ppublish
SO  - Agents Actions. 1992 Sep;37(1-2):39-43. doi: 10.1007/BF01987888.