PMID- 14561924
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 14
IP  - 15
DP  - 2003 Oct 27
TI  - Differential effects of 9-cis, 13-cis and all-trans retinoic acids on the 
      neuronal differentiation of human neuroblastoma cells.
PG  - 1935-9
AB  - A human neuroblastoma cell line IMR-32 was used as an in vitro model to examine 
      three naturally occurring retinoic acid (RA) isomers, 9-cis (9c), 13-cis (13c) 
      and all-trans (AT) RA, in mediating growth differentiation and neuronal 
      differentiation. All RA isomers inhibited cellular proliferation, with 13c-RA 
      being most effective. Cyclic AMP-responsive-element-binding-protein (CREB) was 
      activated during RA treatment. AT-RA was a better differentiating agent in 
      inducing the highest expression of the neurotrophic factor receptor TrkA. After 
      prolonged RA treatment, the expression of RA receptors (RARs) was comparable for 
      the three isomers, but retinoid X receptors (RXRs) were differentially regulated. 
      These results imply that distinctive molecular pathways might be involved in the 
      in vitro differentiation of neuroblastoma with different RA isomers.
FAU - Chu, Patrick W K
AU  - Chu PW
AD  - University Department of Medicine, Queen Mary Hospital, Hong Kong.
FAU - Cheung, William M W
AU  - Cheung WM
FAU - Kwong, Yok L
AU  - Kwong YL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Biomarkers)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
MH  - Biomarkers
MH  - Blotting, Western
MH  - Brain Neoplasms/*pathology
MH  - Cell Differentiation/drug effects
MH  - Cell Division/drug effects
MH  - Cell Line, Tumor
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Humans
MH  - Neuroblastoma/*pathology
MH  - Neurons/*drug effects
MH  - Receptor, trkA/metabolism
MH  - Receptors, Retinoic Acid/drug effects/metabolism
MH  - Retinoid X Receptors
MH  - Signal Transduction/drug effects/physiology
MH  - Stereoisomerism
MH  - Transcription Factors/drug effects/metabolism
MH  - Transfection
MH  - Tretinoin/chemistry/*pharmacology
MH  - beta-Galactosidase/metabolism
EDAT- 2003/10/17 05:00
MHDA- 2004/01/06 05:00
CRDT- 2003/10/17 05:00
PHST- 2003/10/17 05:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/10/17 05:00 [entrez]
AID - 10.1097/00001756-200310270-00011 [doi]
PST - ppublish
SO  - Neuroreport. 2003 Oct 27;14(15):1935-9. doi: 10.1097/00001756-200310270-00011.