PMID- 14562180
OWN - NLM
STAT- MEDLINE
DCOM- 20031208
LR  - 20190901
IS  - 0271-3683 (Print)
IS  - 0271-3683 (Linking)
VI  - 27
IP  - 3
DP  - 2003 Sep
TI  - HLA class II antigen expression in conjunctival precancerous lesions and squamous 
      cell carcinomas.
PG  - 151-5
AB  - PURPOSE: The expression of human leukocyte antigen (HLA) class II molecules on 
      the cell surface is necessary for the presentation of peptide antigens to helper 
      CD4 T lymphocytes of the immune system. We studied the immunoexpression of HLA 
      class II antigen in conjunctival precursor lesions and conjunctival squamous cell 
      carcinomas. METHODS: HLA class II antigen expression was analyzed in 8 
      conjunctival dysplasias, 6 carcinomas in situ and in 7 conjunctival squamous cell 
      carcinomas, by immunoperoxidase staining with monoclonal antibody to HLA class II 
      antigen on the archival clinical samples. Immunoanalysis was done by a semi 
      quantitative method based on the intensity of staining and the percentage of 
      stained cells. RESULTS: HLA class II antigen immunoexpression was heterogeneous 
      in 8 conjunctival dysplasias and in 6 carcinoma in situ and negative in 7 
      conjunctival squamous cell carcinomas. CONCLUSIONS: Human leukocyte class II 
      antigen immunoexpression is decreased in conjunctival precancerous and squamous 
      cell carcinomas.
FAU - Abhyankar, Dhiraj
AU  - Abhyankar D
AD  - Department of Medicine, Evanston Northwestern Healthcare, Evanston, Illinois, USA
FAU - Lakshmi, Sundaram Amirtha
AU  - Lakshmi SA
FAU - Pushparaj, Vaijayanthi
AU  - Pushparaj V
FAU - Biswas, Jyotirmay
AU  - Biswas J
FAU - Krishnakumar, Subramanian
AU  - Krishnakumar S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Carcinoma, Squamous Cell/*immunology
MH  - Conjunctival Neoplasms/*immunology
MH  - Histocompatibility Antigens Class II/*analysis
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Precancerous Conditions/*immunology
MH  - Staining and Labeling
EDAT- 2003/10/17 05:00
MHDA- 2003/12/10 05:00
CRDT- 2003/10/17 05:00
PHST- 2003/10/17 05:00 [pubmed]
PHST- 2003/12/10 05:00 [medline]
PHST- 2003/10/17 05:00 [entrez]
AID - 10.1076/ceyr.27.3.151.16052 [doi]
PST - ppublish
SO  - Curr Eye Res. 2003 Sep;27(3):151-5. doi: 10.1076/ceyr.27.3.151.16052.