PMID- 14563405
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20190901
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 41
IP  - 12
DP  - 2003 Dec
TI  - Classification of contact allergens according to potency: proposals.
PG  - 1799-809
AB  - It is clear that contact allergens vary substantially with regard to the relative 
      potency with which they are able to induce skin sensitisation. Considerations of 
      potency will in the future become a significant factor in the classification of 
      skin sensitising chemicals. It is therefore appropriate to establish what is 
      known of potency and thresholds in the induction of skin sensitisation and the 
      elicitation of allergic contact dermatitis, and to identify approaches that might 
      be available for assessment of relative potency for the purposes of categorising 
      chemical allergens. This paper was prepared by an ECETOC (European Centre for 
      Ecotoxicology and Toxicology) Task Force that had the objective of recommending 
      approaches for the measurement of potency and definition of thresholds for both 
      the induction and elicitation of contact sensitisation. The deliberations 
      recorded here build upon recommendations made previously by an ECETOC Task Force 
      that considered the conduct of standard skin sensitisation test methods for the 
      purposes of hazard identification and risk assessment (ECETOC, Monograph No. 29, 
      Brussels, 2000). The emphasis in this present paper is also on standard and 
      accepted methods for the assessment of skin sensitisation, and for which OECD 
      guidelines are available: the local lymph node assay (LLNA), the guinea pig 
      maximisation test and the occluded patch test of Buehler. For various reasons, 
      discussed in detail herein, attention focused primarily upon consideration of 
      categorisation of chemical allergens and the identification of thresholds with 
      respect to the induction of skin sensitisation, rather than the elicitation of 
      allergic contact dermatitis. It is concluded that although the LLNA is the method 
      of choice for the determination of skin sensitisation potency for the purposes of 
      categorisation, if data are already available from appropriate guinea pig tests 
      then their judicious interpretation may provide information of value in 
      determinations of potency and categorisation. Included here are detailed and 
      specific recommendations for how best the results of the three test methods 
      considered can be used for the categorisation of chemical allergens as a function 
      of skin sensitisation potency.
FAU - Kimber, I
AU  - Kimber I
AD  - Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire 
      SK10 4TJ, UK. ian.kimber@syngenta.com
FAU - Basketter, D A
AU  - Basketter DA
FAU - Butler, M
AU  - Butler M
FAU - Gamer, A
AU  - Gamer A
FAU - Garrigue, J-L
AU  - Garrigue JL
FAU - Gerberick, G F
AU  - Gerberick GF
FAU - Newsome, C
AU  - Newsome C
FAU - Steiling, W
AU  - Steiling W
FAU - Vohr, H-W
AU  - Vohr HW
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*classification/*toxicity
MH  - Animals
MH  - Dermatitis, Allergic Contact/*classification/*pathology
MH  - Guinea Pigs
MH  - Humans
MH  - Immunization
MH  - Local Lymph Node Assay
MH  - Reference Standards
MH  - Skin Tests/classification
EDAT- 2003/10/18 05:00
MHDA- 2003/12/10 05:00
CRDT- 2003/10/18 05:00
PHST- 2003/10/18 05:00 [pubmed]
PHST- 2003/12/10 05:00 [medline]
PHST- 2003/10/18 05:00 [entrez]
AID - S0278691503002230 [pii]
AID - 10.1016/s0278-6915(03)00223-0 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2003 Dec;41(12):1799-809. doi: 10.1016/s0278-6915(03)00223-0.