PMID- 14563541
OWN - NLM
STAT- MEDLINE
DCOM- 20040311
LR  - 20191210
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 72
IP  - 1
DP  - 2003 Oct 24
TI  - Reinforcing, subjective, and physiological effects of MDMA in humans: a 
      comparison with d-amphetamine and mCPP.
PG  - 33-44
AB  - 3,4-methylenedioxymethamphetamine (MDMA) is a widely used drug of abuse 
      chemically related to both the amphetamines and mescaline. Laboratory animal 
      studies have shown that MDMA is a potent re-uptake inhibitor and releaser of 
      dopamine and serotonin. Although the subjective and physiological effects of MDMA 
      have been compared to d-amphetamine in humans, no direct comparison with a 
      serotonin releasing agent has been reported and reinforcing effects have not been 
      evaluated. In this paper we report a direct comparison of the reinforcing, 
      subjective, and physiological effects of MDMA (1 and 2 mg/kg) to d-amphetamine 
      (10 and 20 mg), to metachlorophenylpiperazine (mCPP--a serotonin releasing agent 
      (0.5 and 0.75 mg/kg)), and to placebo using a within-subject design in 12 
      volunteers with moderate MDMA experience. Both the high dose of d-amphetamine and 
      MDMA showed significant reinforcing effects as indicated by high cross-over 
      values on the multiple choice procedure compared to all other treatments. All 
      three drugs showed dose-dependent changes in subjective effects whereas 
      physiological effects were most pronounced for MDMA with almost no changes seen 
      with mCPP. The subjective effects of MDMA were similar both to those of mCPP and 
      d-amphetamine, suggesting that both dopamine and serotonin systems are involved 
      in mediating these effects. In contrast, only the dopaminergic agents, 
      d-amphetamine and MDMA, had reinforcing effects.
FAU - Tancer, Manuel
AU  - Tancer M
AD  - Department of Psychiatry and Behavioral Neurosciences, Substance Abuse Research 
      Division, Addiction Research Institute, Wayne State University, 2761 E Jefferson, 
      Detroit, MI 48207, USA. mtancer@med.wayne.edu
FAU - Johanson, Chris-Ellyn
AU  - Johanson CE
LA  - eng
GR  - 5 K08 DA00370/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Dopamine Agonists)
RN  - 0 (Hallucinogens)
RN  - 0 (Piperazines)
RN  - 0 (Serotonin Receptor Agonists)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Affect/*drug effects
MH  - Cross-Over Studies
MH  - Dextroamphetamine/*pharmacology
MH  - Dopamine Agonists/*pharmacology
MH  - Female
MH  - Hallucinogens/*pharmacology
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Piperazines/*pharmacology
MH  - *Reinforcement, Psychology
MH  - Serotonin Receptor Agonists/*pharmacology
MH  - Severity of Illness Index
MH  - Substance-Related Disorders/*diagnosis/*epidemiology
MH  - Surveys and Questionnaires
EDAT- 2003/10/18 05:00
MHDA- 2004/03/12 05:00
CRDT- 2003/10/18 05:00
PHST- 2003/10/18 05:00 [pubmed]
PHST- 2004/03/12 05:00 [medline]
PHST- 2003/10/18 05:00 [entrez]
AID - S0376871603001728 [pii]
AID - 10.1016/s0376-8716(03)00172-8 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2003 Oct 24;72(1):33-44. doi: 10.1016/s0376-8716(03)00172-8.