PMID- 14568100
OWN - NLM
STAT- MEDLINE
DCOM- 20040812
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 120
IP  - 10
DP  - 2003 Oct
TI  - Differential activities of Sonic hedgehog mediated by Gli transcription factors 
      define distinct neuronal subtypes in the dorsal thalamus.
PG  - 1097-111
AB  - The dorsal thalamus (DT) is a pivotal region in the vertebrate brain that relays 
      inputs from the peripheral sensory organs to higher cognitive centers. It 
      consists of clusters of neurons with relevant functions, called brain nuclei. 
      However, the mechanisms underlying development of the DT, including specification 
      of the neuronal subtypes and morphogenesis of the nuclear structures, remain 
      largely unknown. As a first step to this end, we focused on two transcription 
      factors Sox14 and Gbx2 that are expressed in the specific brain nuclei in the 
      chick DT. The onset of their expression was found in distinct populations of the 
      postmitotic cells in the prosomere 2, which was regulated by the differential 
      activities of Sonic hedgehog (Shh) in a manner consistent with the action as a 
      morphogen. Furthermore, both gain- and loss-of-function results strongly suggest 
      that such distinct inductive activities are mediated selectively by different Gli 
      factors. These results suggest that cooperation of the differential expression of 
      Gli factors and the activity gradient of Shh signaling generates the distinct 
      thalamic neurons at the specific locations.
FAU - Hashimoto-Torii, Kazue
AU  - Hashimoto-Torii K
AD  - Division of Morphogenesis, Department of Embryogenesis, Institute of Molecular 
      Embryology and Genetics, Kumamoto University, Honjo 2-2-1, Kumamoto 860-0811, 
      Japan.
FAU - Motoyama, Jun
AU  - Motoyama J
FAU - Hui, Chi-Chung
AU  - Hui CC
FAU - Kuroiwa, Atsushi
AU  - Kuroiwa A
FAU - Nakafuku, Masato
AU  - Nakafuku M
FAU - Shimamura, Kenji
AU  - Shimamura K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Hedgehog Proteins)
RN  - 0 (High Mobility Group Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (SHH protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Chick Embryo
MH  - Hedgehog Proteins
MH  - High Mobility Group Proteins/metabolism
MH  - Homeodomain Proteins/metabolism
MH  - Neurons/*metabolism
MH  - Signal Transduction/physiology
MH  - Thalamus/embryology/*metabolism
MH  - Trans-Activators/*metabolism
MH  - Transcription Factors/*metabolism
EDAT- 2003/10/22 05:00
MHDA- 2004/08/13 05:00
CRDT- 2003/10/22 05:00
PHST- 2003/10/22 05:00 [pubmed]
PHST- 2004/08/13 05:00 [medline]
PHST- 2003/10/22 05:00 [entrez]
AID - S092547730300217X [pii]
AID - 10.1016/j.mod.2003.09.001 [doi]
PST - ppublish
SO  - Mech Dev. 2003 Oct;120(10):1097-111. doi: 10.1016/j.mod.2003.09.001.