PMID- 14568232
OWN - NLM
STAT- MEDLINE
DCOM- 20040621
LR  - 20191026
IS  - 0753-3322 (Print)
IS  - 0753-3322 (Linking)
VI  - 57
IP  - 8
DP  - 2003 Oct
TI  - Significant association of HLA A2-DR11 with CD4 naive decrease in autistic 
      children.
PG  - 372-4
AB  - Nine autistic children and 37 ethnically homogenous controls were enrolled in the 
      study to assess their human leukocyte antigen (HLA) pattern, and eight healthy 
      children were studied to define their peripheral blood cell subsets. We observed 
      a significant decrease in CD4+ naive and an increase in CD4+ memory T cells in 
      autistic children. These differences were significantly more pronounced in the 
      autistic children bearing the HLA A2 and DR11 alleles. These data support the 
      hypothesis that autism could be due to an immune imbalance occurring in 
      genetically predisposed children.
FAU - Ferrante, Pasquale
AU  - Ferrante P
AD  - Laboratory of Biology, Don C. Gnocchi Foundation, IRCCS, via Capecelatro 66, 
      20148 Milan, Italy. pferrante@dongnocchi.it
FAU - Saresella, Marina
AU  - Saresella M
FAU - Guerini, Franca R
AU  - Guerini FR
FAU - Marzorati, Michela
AU  - Marzorati M
FAU - Musetti, Maria C
AU  - Musetti MC
FAU - Cazzullo, Adriana Guareschi
AU  - Cazzullo AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR11 antigen)
SB  - IM
MH  - Autistic Disorder/blood/*genetics/*immunology
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Child
MH  - Female
MH  - Flow Cytometry
MH  - Gene Frequency/genetics
MH  - HLA-A2 Antigen/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR Serological Subtypes
MH  - Humans
MH  - Male
EDAT- 2003/10/22 05:00
MHDA- 2004/06/24 05:00
CRDT- 2003/10/22 05:00
PHST- 2003/10/22 05:00 [pubmed]
PHST- 2004/06/24 05:00 [medline]
PHST- 2003/10/22 05:00 [entrez]
AID - S0753332203000994 [pii]
AID - 10.1016/s0753-3322(03)00099-4 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2003 Oct;57(8):372-4. doi: 10.1016/s0753-3322(03)00099-4.