PMID- 14570645
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20210902
IS  - 0003-2999 (Print)
IS  - 0003-2999 (Linking)
VI  - 97
IP  - 5
DP  - 2003 Nov
TI  - Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis 
      in human monocytes: possible mechanisms for its effect on inflammation.
PG  - 1312-1316
LID - 10.1213/01.ANE.0000081795.96158.3E [doi]
AB  - The recruitment and activation of peripheral blood monocytes are potentially 
      critical regulatory events for the control of inflammation. Increased levels of 
      monocyte chemoattractant protein (MCP)-1 have been reported in several 
      inflammatory disorders. In this study, we examined the effect of lidocaine on 
      lipopolysaccharide-stimulated MCP-1 secretion and MCP-1 induced chemotaxis in a 
      human monocytic cell line, THP-1. Lidocaine inhibited lipopolysaccharide-induced 
      MCP-1 production as well as messenger RNA expression in a dose-dependent manner. 
      Furthermore, we demonstrated that lidocaine suppressed MCP-1-induced chemotaxis 
      and peak cytosolic-free calcium in THP-1 cells. These results suggest that 
      lidocaine may modulate MCP-1 production and MCP-1-induced activation in 
      inflammatory cells. IMPLICATIONS: Monocyte chemoattractant protein-1 (MCP-1) 
      plays important roles in the inflammatory processes. Lidocaine may modulate 
      MCP-1-induced monocyte response, as reflected by chemotaxis, cytosolic-free 
      calcium, and lipopolysaccharide-induced MCP-1 production by human monocytic THP-1 
      cells.
FAU - Li, Chi-Yuan
AU  - Li CY
AD  - *Departments of Anesthesiology and daggerDivision of Cardiovascular Surgery, 
      Tri-Service General Hospital; and double daggerDepartments of Biochemistry, National Defense 
      Medical Center, National Defense University, Taipei, Taiwan, Republic of China.
FAU - Tsai, Chien-Sung
AU  - Tsai CS
FAU - Hsu, Ping-Ching
AU  - Hsu PC
FAU - Chueh, Sheau-Huei
AU  - Chueh SH
FAU - Wong, Chih-Shung
AU  - Wong CS
FAU - Ho, Shung-Tai
AU  - Ho ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
RN  - 0 (Anesthetics, Local)
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 98PI200987 (Lidocaine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Anesthetics, Local/*pharmacology
MH  - Calcium/metabolism
MH  - Cell Line
MH  - Cell Movement/drug effects
MH  - Chemokine CCL2/*biosynthesis
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - DNA Primers
MH  - Humans
MH  - Inflammation/*pathology
MH  - Lidocaine/*pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Monocytes/*drug effects/*metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Signal Transduction/drug effects
EDAT- 2003/10/23 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/23 05:00
PHST- 2003/10/23 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/23 05:00 [entrez]
AID - 00000539-200311000-00021 [pii]
AID - 10.1213/01.ANE.0000081795.96158.3E [doi]
PST - ppublish
SO  - Anesth Analg. 2003 Nov;97(5):1312-1316. doi: 10.1213/01.ANE.0000081795.96158.3E.