PMID- 14571071
OWN - NLM
STAT- MEDLINE
DCOM- 20040226
LR  - 20171101
IS  - 1018-8665 (Print)
IS  - 1018-8665 (Linking)
VI  - 207
IP  - 3
DP  - 2003
TI  - Poikilodermatous subacute cutaneous lupus erythematosus.
PG  - 285-90
AB  - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) is a distinct subset of 
      lupus erythematosus with unique clinical, immunological and genetic features. 
      Among the unusual variants of SCLE, there is a poikilodermic presentation. 
      However, to date, only 1 case of poikilodermatous SCLE has been reported. 
      OBJECTIVE: Our goal was to summarize the clinical characteristics and course as 
      well as the pathological, laboratory and immunofluorescence findings of 4 
      patients with poikilodermatous SCLE. METHODS: A retrospective study was conducted 
      including 54 patients diagnosed as having SCLE between 1980 and 2002. RESULTS: 
      Four patients (7.4%) had SCLE. All patients were alive, and none developed severe 
      systemic involvement in up to 36 years (median, 24 years) after the onset of 
      disease. The most noteworthy laboratory finding was the cutaneous deposition of 
      amyloid. CONCLUSION: Poikilodermatous SCLE represents an uncommon variant within 
      the clinicopathological spectrum of SCLE following a favorable course, in spite 
      of extensive cutaneous involvement. Photosensitivity is the pathomechanism 
      explaining, theoretically, the development of both poikiloderma and cutaneous 
      amyloidosis in such cases.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Marzano, Angelo V
AU  - Marzano AV
AD  - Institute of Dermatological Sciences of the University of Milan and IRCCS 
      Ospedale Maggiore of Milan, Milan, Italy. avmarzano@everyday.com
FAU - Facchetti, Maura
AU  - Facchetti M
FAU - Alessi, Elvio
AU  - Alessi E
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (Antimalarials)
RN  - 0 (Steroids)
SB  - IM
CIN - Dermatology. 2003;207(3):243-5. PMID: 14571062
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Antimalarials/therapeutic use
MH  - Biopsy, Needle
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Incidence
MH  - Italy/epidemiology
MH  - Lupus Erythematosus, Cutaneous/drug therapy/epidemiology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Rothmund-Thomson Syndrome/drug therapy/epidemiology/*pathology
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Steroids/therapeutic use
MH  - Treatment Outcome
EDAT- 2003/10/23 05:00
MHDA- 2004/02/27 05:00
CRDT- 2003/10/23 05:00
PHST- 2002/12/06 00:00 [received]
PHST- 2003/02/24 00:00 [accepted]
PHST- 2003/10/23 05:00 [pubmed]
PHST- 2004/02/27 05:00 [medline]
PHST- 2003/10/23 05:00 [entrez]
AID - 73091 [pii]
AID - 10.1159/000073091 [doi]
PST - ppublish
SO  - Dermatology. 2003;207(3):285-90. doi: 10.1159/000073091.